无抽搐电休克对抑郁症患者执行功能和生活质量的影响

目的评价无抽搐电休克治疗（MECT）对抑郁症患者执行功能和生活质量的影响。方法将120例抑郁症患者随机分为研究组（MECT合并非典型药物治疗）60例和对照组（单纯非典型药物治疗）60例，同时取60例健康人作为正常组，分别在入组前、治疗3周及6周后对研究组和对照组进行汉密尔顿抑郁量表（HAMD）评定、威斯康星卡片分类任务（WCST）测验及生活质量调查（SF-36）。对正常组进行威斯康星卡片分类任务（WCST）测定。将研究组和对照组治疗3，6周后的威斯康星卡片分类任务（WCST）测验结果及健康状况调查问卷结果与治疗前比较，研究组和对照组治疗第3周和第6周的生活质量分别进行比较。结果治疗6周后两组HAMD总分较治疗前均有显著下降，差异有统计学意义（P〈0．05），WCST中的总应答数、完成分类数、正确数、持续错误数均较治疗前明显改善，差异具有统计学意义（P〈0．05），且治疗3周后研究组在HAMD、WCST方面比对照组改善更为明显，差异具有统计学意义（P〈0．05）。治疗3周后研究组生活质量各因子的分值均明显高于对照组，差异具有统计学意义（t分别为2．23，3．04，4．23，2．56，3．34，2．92，3．65，5．45；P〈0．05），治疗6周后研究组生理职能（RP），身体疼痛（BP），一般健康状况（GH），社会功能（SF），精神健康（MH）因子的分值高于对照组，差异有统计学意义（￡分别为2．97，4．37，3．91，5．21，2．93；P〈0．05）。结论合并MECT治疗能快速改善抑郁患者的症状和执行功能，可以更快、更好地改善患者的生活质量。

The affection of modified electroconvulsive therapy on the executive function and life quality of patients with depression

Objective To evaluate the affect of modified electroconvulsive therapy（MECT） on the executive function and life quality of patients with depression. Methods 120 patients with depression were divided to study group （60 cases） and control group （60 cases）. Both groups were given the same kind of antidepressive drug. Meanwhile, MECT was added in study group. In the study, 60 cases were recruited as normal healthy group. Every patient was evaluated by assessment including Hamilton De- pression Rating Scale （HAMD）, Wisconsin Card Sorting Test （WCST） test and the MOS item short from health survey （SF-36） before treatment, 3 weeks and 6 weeks after treatment. At the same time, the normal group was measured with WCST. The results of WCST and SF- 36 in control group and study group after three and six weeks＇ treatment were compared with the result of before treatment. Re- suits Six weeks after treatment, HAMD scores were lower than those before treatment significantly （P 0. 000）. Total response number, correct number, continual wrong number in WCST of both groups were better than those before treatment significantly （P 〈 0.05）. Additionally, HAMD and WCST scores in study group were better than those in control group （P 〈 0.05 or P 〈 0. 01） after 3 weeks treatment. Meanwhile, after 3 weeks treatment , the SF--36 scores of every factor in study group are all higher than control group significantly （t = 2.23,P = 0. 028;t = 3.04,P = 0. 003;t = 4.23,P = 0. 000; t = 2.56,P = 0. 012;t = 3.34,P = 0. 001;t = 2.92,P = 0. 004;t = 3.65,P = 0. 000;t = 5.45,P = 0. 000）. After 6 weeks treatment, the SF-36 scores of RP （t = 2.97,P = 0. 004）, BP （t = 4.37;P = 0. 000）, GH （t ： 3. 91 ,P = 0. 000）, SF （t = 5.21 ,P = 0. 000）, MH （t = 2.93 ,P = 0. 003） in study group are significantly higher than control group. Conclusions Combination with MECT can improve syndrome of depression and executive function quickly, and improve patient＇s quality of life faster and better.