| 肾综合征出血热病毒感染正常人肝脏组织细胞培养研究 |
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| 引用本文： | 姚智慧 赵洪奎. 肾综合征出血热病毒感染正常人肝脏组织细胞培养研究[J]. 中华实验和临床病毒学杂志, 1995, 9(1): 19-21 |
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| 作者姓名： | 姚智慧 赵洪奎 |
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| 作者单位： | 北京中国药品生物制品检定所，山东聊城地区人民医院 |
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| 摘 要： | 将４个型的９株肾综合征出血热病毒分别感染体外培养的正常人胚肝单层细胞，结果９株均能感染肝细胞，而且繁殖滴度较高，分别在６－１１ｄ达到高峰，其中以从肝分离的Ｌ２０株滴度为高而且维持时间较长。说明了肾综合征出血热病毒对肝脏有直接作用的可能。
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| 关 键 词： | 肾病综合征 出血热 病毒 感染 肝 细胞培养 |
Study on Hantavirus Infected Human Embryonic Liver Cells in Vitro |
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| Yao Zhihui,Zhao Hongkui,Dong Guanmu,et al. Study on Hantavirus Infected Human Embryonic Liver Cells in Vitro[J]. Chinese journal of experimental and clinical virology, 1995, 9(1): 19-21 |
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| Authors: | Yao Zhihui Zhao Hongkui Dong Guanmu et al |
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| Abstract: | Nine strains of Hantavirus belonging to four serotypes were studied for studied for their infectivity in human embryonic liver cells in vitro.The results showed that all the isolated strains could infect liver cells and produce a relatively high virus titers in the supernatant of the cell cultures.The peak titers appeared at 6 to 11 days after infection.Moreover,ones strain (L20) isolated from liver tissue biopsy of a HFRS patient was found to have higher infectivity and a longer period of high titer in the liver tissue culture.It is,therefore,likely that Hantavirus could infect liver tissue directly in vivo and HFRS.(National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050)(Shandong Liaocheng District Hospital 252000) |
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| Keywords: | Hemorrhagic fever with renal syndrome(HFRS) Human embryonic liver cell Tissue culture In vitro |
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