| 沙棘籽油对大鼠急性缺血性脑梗死的保护作用 |
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| 引用本文： | 程体娟,王玉斌,高丽萍,孙以方,张坚.沙棘籽油对大鼠急性缺血性脑梗死的保护作用[J].中国中药杂志,2003,28(6):548-550. |
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| 作者姓名： | 程体娟 王玉斌 高丽萍 孙以方 张坚 |
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| 作者单位： | 1. 兰州医学院,甘肃,兰州,730000
2. 甘肃省人民医院,影像诊断中心,甘肃,兰州,730000 |
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| 基金项目： | 甘肃省自然科学基金资助项目 (ZR 97 10 1) |
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| 摘 要： | 目的 :旨在探讨沙棘籽油对大鼠急性缺血性脑梗死的保护作用。方法 :采用大脑中动脉 (MCA)阻断术制作大鼠缺血性脑梗死模型 ,观察药物对脑梗死大鼠脑梗死体积和行为障碍的影响。结果 :沙棘籽油大剂量 (0 .7g·kg-1)和小剂量 (0.35g·kg-1)均能明显改善MCA阻断大鼠的行为障碍 ,并能减少脑梗死范围。结论 :沙棘籽油对大鼠急性缺血性脑梗死具有明显的保护作用。
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| 关 键 词： | 沙棘籽油 大脑中动脉阻断术(MCAO) 脑梗死 核磁共振成像(MRI) |
| 文章编号： | 1001-5302(2003)06-0548-03 |
| 收稿时间： | 2002/2/21 0:00:00 |
| 修稿时间： | 2002年2月21日 |
The Protection of Seed Oil of Hippophae rharmnoides on Ischemic Cerebral Infarction in Rats |
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| CHENG Ti-juan ;WANG Yu-bin ;GAO Li-ping ;SUN Yi-fang ;ZHANG Jian.The Protection of Seed Oil of Hippophae rharmnoides on Ischemic Cerebral Infarction in Rats[J].China Journal of Chinese Materia Medica,2003,28(6):548-550. |
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| Authors: | CHENG Ti-juan ;WANG Yu-bin ;GAO Li-ping ;SUN Yi-fang ;ZHANG Jian |
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| Institution: | Lanzhou Medical College, Lanzhou 730000, Ganshu, China. litjian@public.lz.gs.cn |
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| Abstract: | Objective: To study the protection of seed oil of Hippophae rhamnoides on ischemic cerebral infarction in rats and the mechanism of the action. Method: Focal cerebral ischemia model was made by middle cerebral artery occlusion(MCAO) in rats. Behavior obstacles of rats were observed. Cerebral infarction volume was determined by Megnetic Resonance Imaging(MRI). Result: Seed oil of Hippophae rhamnides 0.7 and 0.35 g·kg-1 could markedly reduce infarction volume after occlusion of middle cerebral artery in rats and also could ameliorate the behavior obstacles of rats. Conclusion: These results suggested that seed oil of Hippophae rhamnoides had distinct protection to ischemic cerebral infarction in rats. |
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| Keywords: | seed oil Hippophae rhamnodes middle cerebral artery occlusion (MCAO) cerebral infarction magnetic resonance imaging (MRI) |
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