Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating,personality traits,monoamine metabolites in CSF,serum cortisol,platelet MAO and urinary melatonin |
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Authors: | Lars von Knorring Béla G L Almay Jan Häggendal Folke Johansson Lars Oreland Lennart Wetterberg |
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Institution: | (1) Department of Psychiatry, Umeå University, S-90185 Umeå, Sweden;(2) Department of Neurology, Umeå University, S-90185 Umeå, Sweden;(3) Department of Pharmacology, University of Gothenburg, S-41346 Gothenburg, Sweden;(4) Department of Pharmacology, Uppsala University, S-75124 Uppsala, Sweden;(5) Department of Psychiatry, St. Göran's Hospital, Karolinska Institute, S-11281 Stockholm, Sweden |
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Abstract: | Summary The aim of the present study was to investigate the discriminative power of a series of variables (including determination of depressive symptomatology by means of a visual analogue scale, determination of personality traits by means of the Karolinska Scales of Personality, determination of monoamine metabolites in CSF, platelet MAO activities, serum cortisol before and after dexamethasone suppression and urinary melatonin) in differentiating (a) chronic pain patients from healthy subjects, and (b) patients with idiopathic pain syndromes from patients with neurogenic pain syndromes. Separately each of the measures gave a significant but often low contribution to the discrimination, while a combination of several measures gave a complete discrimination both between healthy subjects and patients with chronic pain syndromes and between patients with idiopathic and neurogenic pain syndromes, respectively.Supported in part by grants from the Swedish Medical Research Council (grants no. 3371, 4145 and 5740) and by a grant from Stiftelsen Söderström-Königska Sjukhemmet |
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Keywords: | Chronic pain Neurogenic pain Visual analogue scale Personality traits KSP 5-HIAA HVA Cortisol MAO Dexamethasone Melatonin Discriminant analysis |
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