铜绿假单胞菌对碳青霉烯类抗生素5年耐药率的分析

目的探讨医院内铜绿假单胞菌(PA)对碳青霉烯类抗生素的耐药率及其变迁,以指导临床合理用药。方法采集2001-2005年病房临床分离PA共2 629株,测定对碳青霉烯类抗生素的药敏。结果对亚胺培南和美洛培南的5 a总耐药率分别是49.54%和55.57%。2001年对亚胺培南的耐药率是47.86%,2005年上升到60.59%(P<0.01)。2003年对美洛培南的耐药率是36.63%,2.005年上升到75.23%(P<0.01)。结论PA对碳青霉烯类抗生素的耐药性已十分突出,对于PA的感染,应在药敏指导下用药。碳青霉烯类抗生素的耐药性呈明显上升趋势,应该适当控制碳青霉烯类药物的使用。

Resistance change of pseudomonas aeruginosa to carbapenems in five years

AIM To investigate the change of resistance of Pseudomonas aeruginosa (PA) to carbapenems for ra- tional usage of antimicrobialagent.METHODS The 2 629 PA strains were tested,which were separated from clinical specimen from Jan.2001 to Dec.2005.Snsceptitities to cabapenems were determined.RESULTS Resistance rate of imipenem was 49.54%,and meropenem was 55.57 %.In 2001,the resistant rate of imipenem was 47.86%,while it in- creased to 60.59% (P<0.01 )in 2005.In 2003,the resistant rate of meropenem was 36.63% ,while it increased to 75. 23 % (P<0.01) in 2005.CONCLUSION The resistance rate of PA to carbapenems is obviously increasing.Antimi- crobial treatment of PA infections should be guided by antimicrobial sensitivity test.The clinical usage of carbapenems should be strategically controlled.