肾素血管紧张素系统与高血压血管重构关系的研究进展

高血压血管重构一直是临床和基础研究的热门课题。肾素血管紧张素系统（rennin angiotensinsys-tem,RAS）是人类生理功能的一个重要调节机制,在血管重构方面起重要作用。RAS包括两个轴,即ACE-AngⅡ-AT1受体轴和ACE2-Ang-（1-7）-Mas受体轴。前者通过其主要成员AngⅡ发挥收缩血管和促进血管重构作用,后者则通过七肽的Ang-（1-7）抵消AngⅡ的上述效应。深入认知RAS对高血压血管重构的影响,将为降低高血压病的心血管危险提供更多的新思路。

Progress of the study on relations between renin angiotensin system and vascular remodeling of hypertension

Hypertensive vascular remodeling has always been a hot program in clinic and basic research.Renin-angiotensin system is an importent regulatory mechanism of human physiological function,which plays a fundamental role in vascular remodel- ing.RAS consists of two axes, ACE-AngII-AT_1 receptor axis and ACE2-Ang（1- 7）-Mas receptor axis.The former affects vasoconstriction and promotes vascular re-modeling through its key member,AngII;the latter offsets the effect of the mentioned AngII with the help of seven-peptide Ang-（1-7）.A deep knowledge of the relation between RAS and vascular remodeling would provide more remedies for reducing cardiovascular risk.