Characteristics and drug responses of cochlear and vestibular adenylate cyclase |
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| Authors: | Dan Bagger-Sjöbäck Carol S. Filipek Jochen Schacht |
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| Affiliation: | (1) Kresge Hearing Research Institute, University of Michigan, 48 109 Ann Arbor, MI, USA;(2) Present address: Department of Otolaryngology, Karolinska Sjukhuset, Stockholm, Sweden |
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| Abstract: | Summary Adenylate cyclase activity of dissected cochlear and vestibular structures was assayed with the ATP-analog adenylyl imidodiphosphate as substrate. High activities (per mg protein) were found in stria vascularis and in vestibular preparations, lower activities in spiral ligament, VIIIth nerve, and organ of Corti. The enzyme from all structures was stimulated by fluoride, guanylyl imidodiphosphate or manganese(II) ions, and strongly inhibited by ethacrynate and lead ion. The anti-cancer drug cis-diammine-dichloro platinum significantly inhibited adenylate cyclase from stria vascularis.Presented at the 16th Workshop of Inner Ear Biology in Bern 1979 |
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| Keywords: | Adenylate cyclase in vitro Labyrinthine structures Activators Ototoxic drugs Metal ions |
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