木莲属土厚朴的研究

调查发现一些地区将木莲属(Manglietia)植物桂南木莲、川滇木莲等的树皮代厚朴药用,称为“土厚朴”。用高效液相色谱法,分析了他们所含的厚朴酚(magnolol)、和厚朴酚(honokiol)和木兰箭毒碱(magnocurarine),柳叶木兰碱(salicifoline)及武当木兰碱(magnosprengerine)的含量。研究结果表明,厚朴与土厚朴的生药均有香气和苦辛味,但后者较弱;它们都含有相同的活性成分,但土厚朴的酚类成分含量较低,而木兰箭毒碱含量较高。

STUDIES ON THE MEDICINAL PLANTS OF MAGNOLIACEAE TU-HOU-PO OF MANGLIETIA

Data from a survey of the drug market and investigation of the original plant of "Tu-hou-po", after careful botanical examinations, showed that the drugs were derived from 5 species of the genus Manglietia of Magnoliaceae, viz. Manglietia chingii Dandy, M. insignis (Wall.) Bl., M. duclouxii Finet et Gagnep., M. yuyuanensis Law and M. szechuanica Hu. Comparisons of the main characteristics of the plants, Tu-hou-po and Hou-po crude drugs and chemical components showed that Manglietia is taxonomically the closest to Magnolia and contained similar components (tab 1-2 and fig 1). The results of HPLC analysis demonstrated that they contained magnolol, honokiol, magnocurine and salicifoline, in different quantities. However, no magnosprengerine was detected. Besides, it was also found that the percentage of magnolol and honokiol contents were higher, while that of magnocurine was lower in Hou-po. On the contrary, the content of magnocurine was higher, while that of magnolol and honokiol were lower in Tu-hou-po. Manglietia chingii (Tu-hou-po) is being used as the Chinese traditional drug "Hou-po" in the clinic in Guangxi. Therefore, M. chingii is noteworthily exploited as a new resource of Hou-po for further research.