肉毒毒素治疗肌张力障碍疾病138例疗效观察

目的：观察肉毒毒素治疗肌张力障碍疾病的临床疗效。方法：对68例偏侧面肌痉挛（HFS），50例眼睑痉挛（BS），17例Meige综合征。3例痉挛性斜颈进行面颈部肌肉局部多点注射A型肉毒毒素治疗，评价其治疗效果并观察其主要不良反应。结果：68例HFS完全缓解23例（34%），明显缓解41例（60%），部分缓解4例（6%），有效率达100%。50例BS完全缓解22例（44%），明显缓解26例（52%），部分缓解2例（12%），有效率达100%。17例Meige综合征完全缓解6例（35%），明显缓解9例（53%），部分缓解2例（12%），有效率达100%。3例痉挛性斜颈，2例部分性缓解，1例无效，起效时间平均3d，缓解维持时间平均9个月，局部副作用轻微、短暂且无明显全身反应及过敏反应。结论：用A型肉毒毒素治疗肌张力障碍局限性肌肉痉挛，是一种有效、副作用少、操作简便易行的治疗方法。

An observation of the efficancy by injection of botulinum toxin type A in the treatment of 138 cases in dystonia

Objective: To study the efficacy of the injection of botulinum toxin type A made in China (CBTX-A) for the treatment of hemifacial spasm (HFS), blepharospasm (BS), Meige's sydorme and spasmodic torticollis (CD). Method: 68 cases with HFS, 50 cases with BS, 17 cases with Meige's syndrome and 3 cases with CD were evaluated on therapeutic efficancy of multifocal facial injection and the main side effects that caused by the method of therapy were observed. Results: Of the 68 cases with HFS, 23(34%) patients were completely relieved, 41(60%) cases remarkably relieved, 4(6%) cases partially relieved; all of the patients experienced relief from spasm. Of the 50 patients with BS, 22(44%) were completely relieved, 26(52%) cases remarkably relieved, 2(4%) partially relieved, the effective rate was 100%. Of the 17 cases with Meige's syndrome, 6(35%) were completely relieved, 9(53%) were remarkably relieved, 2(12%) partially relieved, the effective rate was also 100%. Of 3 cases with CD, 2 cases were partially relieved, one was in vain. Observation showed that the time for marked improvement in symptoms after injection was average 3 days and lasted 9 months. The local side effects were transient and mild, no systemic adverse and allergic reaction were noted. Conclusion: The injection of CBTX-A for treatment of dystonia is effective and simple, at the same time, the side effects are very low.