| 川芎嗪和异博定联合逆转HL60／HT细胞的多药耐药 |
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| 引用本文： | 梁蓉,杨平地.川芎嗪和异博定联合逆转HL60／HT细胞的多药耐药[J].第四军医大学学报,1998,19(4):785-787. |
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| 作者姓名： | 梁蓉 杨平地 |
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| 作者单位： | 第四军医大学西京医院血液内科!西安，710033，第四军医大学西京医院血液内科!西安，710033，第四军医大学西京医院血液内科!西安，710033 |
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| 基金项目： | 陕西省自然科学计划资助!97SM53 |
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| 摘 要： | 目的：观察中药钙通道阻滞剂川芎嗪（ＴＭＰ）和异博定（ＶＰ）对白血病ＨＬ６０／ＨＴ耐药细胞系多药耐药（ＭＤＲ）的逆转。
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| 关 键 词： | 川芎嗪 异博定 多药耐药 逆转 白血病 |
Reversal of multidrug resistance of HL60/HT leukemia cell line by combination of tetramethylpyrazine and verapamil |
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| LIANG Rong, YANG Ping-Di, CHEN Xie-Qun.Reversal of multidrug resistance of HL60/HT leukemia cell line by combination of tetramethylpyrazine and verapamil[J].Journal of the Fourth Military Medical University,1998,19(4):785-787. |
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| Authors: | LIANG Rong YANG Ping-Di CHEN Xie-Qun |
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| Abstract: | Aim:To investigate the reversal of multidrug resistance (MDR) of leukemia cell lines HL60/HT by traditional calcium channel blocker tetramethylpyrazine (TMP)and verapamil (VP). Methods:The drug sensitivity test wasperformed with MTT and the concentration of daunorubicin(DNR) in cells was measured by flow cytometer (FCM).Results: The cytotoxicity of DNR to HL60/HT was enhanced by TMP and (or) VP at nontoxic doses, the effectwere VP (1 mg/L) +TMP>VP (1 mg/L), VP (0. 32 mg/L ) +TMP>TMPM 0. 32 mg/L VP, and the effect of VP(0. 32 mg/L) +TMP was similar to that of VP (1 mg/L).Meanwhile TMP and (or ) VP increased the concentration of DNR in cells. And the effects were VP(1 mg/L) +TMP>VP (1 mg/L) >TMP. Conclusion: For the reversaleffect of VP was enhanced by being combined with TMP,TMP may be a safe and effective revertant to MDR. |
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| Keywords: | tetramethylpyrazine verapamil multidrugResistance daunorubicin |
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