Post-ingestive effects of quinine on intake of nutritive and non-nutritive substances

Intragastric intubation of 0.75 g QHCl had no effect on 4 hr food intake, but produced anorexia over a 24 hr period when paired with consumption of a novel sucrose octa acetate (SOA) treated chow. No anorexia developed when a familiar food was available. SOA adulteration alone produced a decrement in food intake that persisted for 4 hr; this effect was independent of quinine intubation. In a second experiment, intubation of 0.375 or 0.75 g QHCl, 0.3 M LiCl, or 0.6 g SOA did not alter 4 hr chow intake, but QHCl and LiCl both produced pica that lasted for 4 hr. SOA and 0.75 g QHCl produced a 24 hr hyperphagia, while LiCl and 0.375 g QHCl produced no change in 24 hr chow intake.