中西医结合分期综合防治方案对痛风患者生活质量的影响

目的调查痛风患者的生活质量及其影响因素,观察中西医结合分期综合防治方案对痛风患者生活质量的干预效果。方法将120例痛风急性发作72h以内患者随机分为治疗组和对照组,每组60例。治疗组急性期予虎杖痛风颗粒、双氯芬酸钠缓释胶囊口服和金黄膏外敷,间歇期予茵连痛风颗粒和苯溴马隆片口服;对照组急性期予双氯芬酸钠缓释胶囊口服,间歇期予苯溴马隆片口服。两组疗程均为12周。治疗前后进行生活质量问卷调查。结果治疗前,两组患者生理功能、心理功能、社会功能、健康自我认识和总评分比较,差异均无统计学意义(P>0.05)。与本组治疗前比较,治疗后两组患者上述4个方面单项评分及总评分均有显著提高(P<0.01),且治疗组改善程度优于对照组(P<0.01)。不同性别、年龄阶段、婚姻状况、受教育程度以及有无伴发疾病的痛风患者生活质量总评分比较,差异均无统计学意义(P>0.05);而有关节僵硬、畸形的患者生活质量总评分明显低于无关节僵硬、畸形患者(P<0.01)。痛风患者的生活质量总评分与病程长短显著相关(r=-0.324,P<0.01)。结论痛风患者的生活质量与病程及有无关节僵硬、畸形相关,中西医结合分期综合防治方案对提高患者生活质量具有明显的作用。

Stage-based Treatment of Integrative Medicine on the Quality of Life in Patients with Gout

Objective To investigate the quality of life in patients with gout and their influencing factors,and to observe the effects of the intervention program of stage-based treatment of integrative medicine(IM).Methods Totally 120 patients with acute attack of gout within 72 h were randomly assigned to the treatment group and the control group,60 in each group.Patients in the treatment group were treated with Huzhang Tongfeng Granule(HTG),diclofenac sodium extended-release capsule and Jinhuang Ointment(JO)in the acute stage,and Yinlian Tongfeng Granule(YTG)and Benzbromarone Tablet(BT)in the intermission stage.Patients in the control group were treated with diclofenac sodium extended-release capsule in the acute stage,and BT in the intermission stage.All patients were treated for 12 weeks.The quality of life(QOL)before and after treatment was investigated by questionnaire.Results Before treatment there were no statistical difference in the physiological function,psychological function,social function,health self-awareness and total score between the two groups(P>0.05).After treatment the scores of the four aspects and the total score were significantly improved in the two groups(P<0.01).And the improvement of the treatment group was better than that of the control group(P<0.01).There was no statistical difference in the gender,age,marital status,educational level,QOL with or without associated disease between the two groups(P>0.05).The QOL of patients with joint stiffness or deformity was less than that of those without joint stiffness or deformity(P<0.01).The total QOL scores of the gout patients were obviously correlated with the course of diseases(r=-0.324,P<0.01).Conclusions The QOL of patients with gout was correlated with the course of disease and joint stiffness or deformity.Stage-based treatment of IM could significantly improve the QOL of gout patients.