从雌激素样活性解析中药诱导神经干细胞增殖及分化

中医药治疗神经退行性疾病的临床历史悠久,而近年来中药诱导神经干细胞增殖和分化的现代药理学研究进展迅速。为了发掘传统中医学理论的有关阐述与现代药理学研究成果的内在联系,笔者通过总结中药诱导神经干细胞增殖与分化的研究进展,以中医滋补肝肾理论及益气活血理论为出发点,结合雌激素诱导神经干细胞增殖与分化的研究成果,提出中药雌激素样活性滋补肝肾是中药诱导神经干细胞增殖分化的机制之一。

Chinese Materia Medica Estrogen-like Active Substances Induce the Proliferation and Differentiation of the Neural Stem Cells

Chinese medicine(CM) and Chinese materia medica(CMM) have a long history in treating neurodegenerative diseases.In recent years great progress has taken place in modern pharmacological studies on CMM inducing the proliferation and differentiation of neural stem cells(NSCs).In order to find out the internal correlation between classic CM theories and modern pharmacological achievements,the author raised that the estrogen-like activity of nurturing Gan and Shen CMM is one of CMM’s mechanisms for inducing the proliferation and differentiation of NSCs through summarizing the progress of CMM’s inducing the proliferation and differentiation of NSCs,taking nurturing Gan and Shen as the starting point,and combining the achievements of estrogen’s inducing the proliferation and differentiation of NSCs.