脑源性神经营养因子与脑缺血肺水肿

脑缺血肺水肿（BIPE）是神经源性肺水肿（NPE）的一种主要类型，起病急，病死率高，开展其机制研究，有重要的科学意义和现实价值。NPE的发生不是单一因素，而是一个复杂的病理生理过程，是中枢神经系统损伤后神经、体液、生物活性因子等多因素综合作用的结果。本专题研究结果表明，脑源性神经营养因子（BDNF）在BIPE发病机制中有重要作用，未来有望将其用于BIPE的治疗。

The Role of BDNF in Brain Ischemia Pulmonary Edema

【Abstract】 Brain ischemia pulmonary edema（BIPE）is a critical type of the neurogenic pulmonary edema (NPE), with acute development and progression and high mortality. The study on mechanism of BIPE has important scientific significance and substantial practice values. NPE, as a complicated physiopathology condition, is not resulted from single factor but systemic events including the changes in nervous system, body fluid regulation and endocrine involved in central nervous system after the injury. The studies on this topic in this current issue suggested that brain-derived neurotrophic factor (BDNF) could involve in the pathogenesis procedure of NPE following brain ischemia, which indicated that the crucial role of BDNF in the NPE after BIPE. The findings of these studies pave a way for the treatment of BIPE by using BDNF administration in future clinic trail.