降纤酶治疗急性脑梗塞的疗效观察及血浆纤维蛋白原改变的初步讨探

目的 观察降纤酶治疗急性脑梗塞的疗效及血浆纤维蛋白原的改变，为进一步的临床研究提供一些参考依据。方法 采用随机双育、安慰剂对照的多中心临床试验的方法，将85例急性脑梗塞患随机分为两组即研究组(降纤酶组)和对照组(安慰剂组)，于用药前后作神经功能缺损评分，并且检测血浆纤维蛋白原(FIB)，凝血酶原时间(PT)，血小板计数(PLT)，出血时间(BT)，凝血时间(CT)。结果 研究组的神经功能缺损程度明显改善，治愈率和有效率均高于对照组(P＜0．05或P＜0．01)；研究组血浆纤维蛋白原降低，在治疗后第4、6、8、10天与对照组比较有显著差异(P＜0．01)，用药前后PT、PLT、BT、CT均无明显变化。结论 降纤酶治疗急性脑梗塞能明显改善神经功能，且有良好的安全性；控制血浆纤维蛋白原水平是治疗的关键。

A study on the efficacy of ancord and changes of fibrinogen in patients with acute cerebral infarction

Objective To observe the therapeutic effectiveness of ancord and the changes of serum fibrinogen in patients with acute cerebral infarction, in order to provide valuble evidence for further climical study. Methods A multicenter, double-blind, randomized, and placebo controlled clinical trail was carried out. 85 patients with acute cerebral infarction were divided into two groups. One group was given ancord treatment and other was given placebo treatment. FIB, CT, BT, PT and PLT were tested before and after treatment and compared with the placebo control group, the function of neurological system was examined at the same time. Results Ancord treament group could obviously improve neural function and therapeutic effect ( P <0.05 or P <0.01), meanwile the serum FIB eviedently decreased at 4d, 6d, 8d, 10d after ancord treatment compared with placebo controlled group, but PT, BT, CT and PLT without distinct changes. Conclusion It is a effective and safe way to treat acut cerebral infarction with ancord. On the other hand, it is a key point that ancord decrease FIB in the course of treatment.