米非司酮联合米索前列醇用于中孕引产的观察

目的：探讨米非司酮联合米索前列醇用于中期妊娠引产的临床效果。方法：选择2007年～2010年间孕14-26周引产的孕妇120例。随机分成2组，观察组60例，用米非司酮150mg＋米索前列醇600ug引产；对照组60例，采用利凡诺尔100mg羊膜腔内注射引产。结果：2组用药至宫缩发动时间、宫缩发动至胎儿胎盘娩出时间，2小时产后出血量、胎盘胎膜残留量、软产道损伤等方面比较差异有统计学意义（P〈0．05）；在引产成功率、药物副反应等方面比较差异无统计学意义。结论：药物引产效果优于利凡诺尔羊膜腔穿刺引产，米非司酮联合米索引产是一种安全有效的引产方法。

Mifepristone Combined With Misoprostol for Induction of Labor in Midpregnancy

Objective： To discuss the clinical effect of mifepristone combined with misoprostol for induction of labor in midpregnancy. Methods： From Oct. 2007 to Oct. 2010, 120 pregnant women between 14-26 weeks were selected and randomly divided into two groups： observation group and control group. Cases in ob- servation group took mifespristone 150mg orally and following by misoprostol 0.4mg given by oral plus 0.2mg by vagina. And for cases in control group, rivanol 100mg was injected into the amniotic cavity. Results： There was a statistical significance in the time from medicine administration to beginning of uterine contraction, the time from beginning of uterine contraction to foetal placental expulsion, vaginal bleeding volume within 2 hours after delivery, afterbirth residual volume and soft birth canal injury between two groups （P〈0.05）. But there was no significant difference in the achievement ratio of induced labor and the adverse reaction of medicine such as nausea or vomiting and so on. Conclusion： Mifepristone combined with misoprostol is a safe and an effective method for induction of labor in midpregnancy and the effect is better than amniocen- tesis abortion with rivanol.