Interleukin 5 activity in sera from patients with eosinophilia |
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| Authors: | Hideo Enokihara Hiroshi Kajitani Shigeki Nagashima Satoshi Tsunogake Naoto Takano Kenji Saito Shimpei Furusawa Hideo Shishido Yasumichi Hitoshi Kiyoshi Takatsu |
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| Affiliation: | Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan. |
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| Abstract: | Sera from 10 patients with eosinophilia contained eosinophil colony stimulating factor (Eo-CSF) activity. Using anti murine (m) interleukin-5 (IL-5) antibody, we demonstrated that this activity was mainly derived from IL-5. Administration of prednisolone to patients decreased both Eo-CSF activity in sera and the number of eosinophils in blood. These results extend our recent study demonstrating that T cells from eosinophilic patients produce IL-5 with IL-2 stimulation and may support the speculation that IL-5 is an important factor which induces eosinophilia. |
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