脐血造血细胞培养与脐血治疗再生障碍性贫血的疗效

目的 研究观察脐血造血细胞含量、特性，为脐血的临床应用，特别是对成人脐血移植进行基础研究。方法 应用细胞培养技术，在脐血中成功地培养出ＣＦＵ－Ｅ、ＢＦＵ－Ｅ、ＣＦＵ－Ｇ、ＣＦＵ－ＧＭ及ＣＦＵ－Ｆ等多种造血祖细胞，并应用脐血输注治疗再生障碍性贫血（ＡＡ）４０例。结果 脐血各系造血祖细胞显高于成人外周血，而且与成人骨髓培养结果近似。脐血输注治疗ＡＡ显优于传统的治疗方法。结论 脐血输注是ＡＡ患的一

Culture of Hemopoietic Progenitor Cells from Cord Blood and the Effects of Cord Blood Transfusion for Aplastic Anemia Therapy

Objective:To evaluate the quantity and property of the progenitor cells originated from cord blood,and to take the basic study for using cord blood in clinical therapy, especially in cord blood transplantation. Methods: The progenitor cells form cord blood were cultured in vitro. Cord blood were transfused to 40 patients with aplastic anemia. Results:Hemopoitic pro-genitor cells,such as CFU-E,BFU-E,CFU-G,CFU-GM and CFU-F were successfully cultured from cord blood. The quanti-ty of progenitor cells was higher than that of peripheral blood and was similar to that of adult bone marrow. The cord blood transfusion had better therapeutic effects for aplastic anemia than the traditional way. Conclusions: Cord blood transfusion may be a new effective therapeutic way for aplastic anemia, and cord blood transplantation may replace the bone marrow transplantation.