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Accuracy of whole-body FDG-PET and FDG-PET/CT in M staging of nasopharyngeal carcinoma: A systematic review and meta-analysis
Authors:Ming-Che Chang  Jin-Hua Chen  Ji-An Liang  Kuang-Tao Yang  Kai-Yuan Cheng  Chia-Hung Kao
Institution:1. Department of Nuclear Medicine and PET Center, Changhua Christian Hospital, No. 135, Nanxiao Street, Changhua 500, Taiwan;2. Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, No. 666, Buzih Road, Beitun District, Taichung City 40601, Taiwan;3. Biostatistics Center and Graduate Institute of Biostatistics, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404, Taiwan;4. School of Medicine, China Medical University, Taichung, Taiwan;5. Department of Radiation Oncology, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, Taiwan;6. Department of Nuclear Medicine and PET Center, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, Taiwan
Abstract:

Background

A meta-analysis was conducted to evaluate the accuracy of whole-body positron emission tomography (PET) or PET/CT in M staging of nasopharyngeal carcinoma (NPC).

Methods

Through a search of relevant English language studies from October 1996 to September 2011, pooled estimated sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, and summary receiver operating characteristic (SROC) curves of whole-body PET or PET/CT in M staging of NPC were calculated.

Results

Three PET and 5 PET/CT studies were identified. The pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of FDG-PET or PET/CT were 0.83 (95% confidence interval CI], 0.77–0.88), 0.97 (95% CI, 0.95–0.98), 23.38 (95% CI, 16.22–33.69), and 0.19 (95% CI, 0.13–0.25), respectively. The area under curve was 0.9764 and Q* index estimate was 0.9307 for FDG-PET or PET/CT.

Conclusion

Current evidence confirms the good diagnostic performance of the whole-body FDG-PET or PET/CT in M staging of NPC.
Keywords:Nasopharyngeal carcinoma  PET  PET/CT  Staging  Meta-analysis
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