Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: A preliminary study |
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| Authors: | Viviane Rostirola Elsner,Gisele Agustini Lovatel,Felipe Moysé s,Karine Bertoldi,Christiano Spindler,Laura Reck Cechinel,Alysson Renato Muotri,Ionara Rodrigues Siqueira |
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| Affiliation: | 1. Departamento de Farmacologia, Rua Sarmento Leite, 500, 90050-170, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;2. Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Rua Sarmento Leite, 500, 90050-170, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;3. Programa de Pós-Graduação em Ciências Biológicas: Neurociências, Rua Sarmento Leite, 500, 90050-170, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;4. University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children''s Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA |
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| Abstract: | Regular exercise improves learning and memory, including during aging process. Interestingly, the imbalance of epigenetic mechanisms has been linked to age-related cognitive deficits. However, studies about epigenetic alterations after exercise during the aging process are rare. In this preliminary study we investigated the effect of aging and exercise on DNA methyltransferases (DNMT1 and DNMT3b) and H3-K9 methylation levels in hippocampus from 3 and 20-months aged Wistar rats. The animals were submitted to two exercise protocols: single session or chronic treadmill protocol. DNMT1 and H3-K9 methylation levels were decreased in hippocampus from aged rats. The single exercise session decreased both DNMT3b and DNMT1 levels in young adult rats, without any effect in the aged group. Both exercise protocols reduced H3-K9 methylation levels in young adult rats, while the single session reversed the changes on H3-K9 methylation levels induced by aging. Together, these results suggest that an imbalance on DNMTs and H3-K9 methylation levels might be linked to the brain aging process and that the outcome to exercise seems to vary through lifespan. |
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| Keywords: | Aging Exercise Rat hippocampus Epigenetic mechanisms Methylation markers |
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