白介素-13和哮喘发病的研究进展

支气管哮喘（简称哮喘）是一种严重威胁人类健康的慢性呼吸道疾病。在世界范围内,过敏性哮喘的发病率和病死率逐年上升。研究表明,哮喘的发病是由于Th2型细胞过度释放细胞因子后诱导IgE产生,导致肥大细胞和嗜酸粒细胞脱颗粒,引起气道速发性过敏反应和以嗜酸粒细胞、肥大细胞、T细胞等多种炎症细胞参与的慢性气道炎症。白介素-13（IL-13）是一种由CD4^＋、Th2型细胞分泌的多效性细胞因子,介导变态反应的发生,与哮喘的发生有密切的关联。

New progression of interleukin-13 in asthma

Bronchial asthma(asthma) is a kind of respiratory diseases which threatens the health of human being.In the world,the incidence and case fatality of allergic asthma are increasing.Th2-type cell overreleases the cytokine,which can induce generation of IgE and result in mast cells,eosinophile granulocyte cell degranulation.All these cause airway tachy allergic response and chronic inflammation involved by multiple inflammation cells such as eosinophile granulocyte,mast cells,T leukomonocyte.Interleukin-13 is a kind of pleiotropy cytokines which excreted by CD4+,Th2 type cell,and it can mediate allergy.