大黄对全身炎症反应综合征患者凝血功能的影响

目的 :探讨大黄对全身炎症反应综合征 (SIRS)患者凝血功能的影响机制。方法 :36例无凝血功能障碍的SIRS患者随机分为二组 ,对照组 18例给予常规抗炎及支持对症治疗 ,治疗组 18例加用生大黄粉 6 0g/天煎制后分 3次鼻饲。分别检测二组患者治疗前、治疗后 1、3、7天的血浆凝血酶原时间、血小板计数和血浆血管性假血友病因子 (vWF)含量。结果 :治疗后治疗组第 7天的检测指标与对照组比较有显著差异。结论 :大黄对SIRS患者的凝血功能有保护作用。

Influence of Dahuang on Blood Coagulate Function of Patients with Systemic Inflammatory Response Syndrome

Objective:To investigate the mechanism of Dahuang on the blood coagulate function of patients with systemic inflammatory response synd rome.Method:36 patients with systemic inflammatory response syndrom e without coagulate disfunction were put into two groups at ramdom,18 patients i n the control group were accepted normal antiinflammatory and support treatments ,and 18 patients in the therapy group were also accepted Dahuang 60 g/d feeded b y nose.Patients in two groups were examined the plasma prothrombin time and the platelet count and the von Willebrand factor content before therapy and after t reatment 1 day,3 days and 7 days.Results:In the therapy group the 7th days outcome compared with the control group have obvious difference.Conclusion:Dahuuang can protect the blood coagulate function of patients with systemic inflammatory response syndrom.