Functional roles of TRPC channels in the developing brain |
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| Authors: | Yilin Tai Shengjie Feng Wanlu Du Yizheng Wang |
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| Institution: | (1) Laboratory of Neural Signal Transduction, Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Shanghai, 200031, China;(2) Graduate School, Chinese Academy of Science, 320 Yueyang Road, Shanghai, 200031, China |
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| Abstract: | Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels formed by homomeric or heteromeric complexes of TRPC proteins that contain six transmembrane
domains. These channels can be activated through a phospholipase-C-dependent mechanism, making them sensors for environmental
cues. Their expression begins early in embryonic days and remains in adulthood. These channels have important roles in the
processes of neuronal development, including neural stem cell proliferation, cerebellar granule cell survival, axon path finding,
neuronal morphogenesis, and synaptogenesis. In this review, we will discuss functional implications of TRPC channels during
brain development. |
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| Keywords: | Neurone Brain Development TRP channels Synaptic mechanisms |
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