| 卵巢切除所致肾虎对免疫性关节炎小鼠血清骨钙素和肿瘤坏 … |
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| 引用本文： | 徐世杰,吕爱平. 卵巢切除所致肾虎对免疫性关节炎小鼠血清骨钙素和肿瘤坏 …[J]. 中国中西医结合杂志, 1999, 19(1): 34-36 |
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| 作者姓名： | 徐世杰 吕爱平 |
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| 作者单位： | 中国中医研究院基础理论研究所 |
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| 摘 要： | 目的：探讨卵巢切除所致肾虚影响免疫性关节炎（痹证）中骨代谢的机制。方法：切除小鼠卵巢后，Ⅱ型胶原皮下注射以诱导关节炎（ＣＩＡ）；每周１次观察小鼠的关节肿胀程度；组织切片光镜下观察小鼠滑膜、关节软骨及骨的改变；放射免疫法检测小鼠血清雌二醇、骨钙素、肿瘤坏死因子的变化。结果：切除卵巢的小鼠，血中雌二醇水平明显下降，而血清骨钙素和肿瘤坏死因子的含量则显著增加；同时，滑膜组织炎症加重，软骨损伤及破坏均更为
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| 关 键 词： | 肾虚 卵巢切除 痹证 雌二醇 骨钙素 |
Effect of kidney deficiency caused by ovariectomy on serum osteocalcin level and tumor necrosis factor in mice with collagen induced arthritis] |
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| S Xu,A Lu,A Wang. Effect of kidney deficiency caused by ovariectomy on serum osteocalcin level and tumor necrosis factor in mice with collagen induced arthritis][J]. Chinese journal of integrated traditional and Western medicine, 1999, 19(1): 34-36 |
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| Authors: | S Xu A Lu A Wang |
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| Affiliation: | Department of Pathology, Institute of Basic Theory, China Academy of TCM, Beijing (100700). |
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| Abstract: | OBJECTIVE: To explore the effect of ovariectomy caused Kidney Deficiency on the metabolism of bone in mice with collagen induced arthritis. METHODS: The mice for experiment were immunized with subcutaneous injection of type II collagen to induce arthritis after ovariectomy. Severity of joint swelling, radioimmunoassay of serum estradiol (E2), osteocalcin (OC) and tumor necrosis factor (TNF), and pathological changes of joint, including changes on synovia, articular cartilage and bone, were observed once weekly. RESULTS: The E2 level of ovariectomized mice dropped down obviously, while the contents of OC and TNF increased significantly. Severe pathological changes can be seen in synovial tissues, cartilage and bone. CONCLUSION: Kidney Deficiency caused by ovariectomy exacerbated the pathological changes of collagen-induced arthritis in mice. |
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