| 高效液相色谱法测定香砂养胃丸中厚朴酚与和厚朴酚的含量 |
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| 引用本文： | 干国平,熊丽,陆海涛,王来友. 高效液相色谱法测定香砂养胃丸中厚朴酚与和厚朴酚的含量[J]. 中国药学杂志, 2002, 22(12): 734-736 |
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| 作者姓名： | 干国平 熊丽 陆海涛 王来友 |
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| 作者单位： | 1.武汉市药品检验所，湖北武汉430061； 2.武汉市儿童医院，湖北武汉430014； 3.中山大学生命科学院，广东广州510275 |
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| 摘 要： | 目的：建立和改进香砂养胃丸含量测定方法。方法：以HypersilODSC18(5μm,150 mmX4.6 mm)色谱柱分离厚朴酚与和厚朴酚,流动相乙腈-水-冰醋酸(50:48:2)，检测波长294 nm。结果：线性范围：厚朴酚1.12～5.60μgr=0.9999(n=5)，和厚朴酚0.8288～4.144 μg, r=0.9999(n=5)。厚朴酚平均回收率99.1 %，RSD=1.64% (n =5)，和厚朴酚平均回收率102.4%,RSD=1.67%(n=5)。结论：本法简便，快速，准确，可作为该制剂质量控制的方法。
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| 关 键 词： | 香砂养胃丸 厚朴酚 和厚朴酚 高效液相色谱法 |
| 收稿时间： | 2001-10-31; |
HPLC determination of magnolol and isomagnolol in Xiangsha yangwei pills by HPLC |
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| GAN Guo-Ping,XIONG Li,LU Hai-Tao,et al. HPLC determination of magnolol and isomagnolol in Xiangsha yangwei pills by HPLC[J]. Chinese Pharmaceutical Journal, 2002, 22(12): 734-736 |
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| Authors: | GAN Guo-Ping XIONG Li LU Hai-Tao et al |
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| Affiliation: | Wuhan Institude control of Drug, Hubei Wuhan 430061 |
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| Abstract: | OBJECTIVE To establish and improve an HPLC method for the determination of magnolol and isomagnolol in Xiangsha Yangwei pills. METHODS Magnolol and iso-magnolol were separated on Hypersil ODS C18 column(5 μm, 150 mmX 4.6 mm) and detected at 294 nm, using acetonitrile-water-acetic acid glacial (50:48:2) as mobile phase. RESULTS The standard curves for magnolol and magnolol were linear in the range of 1.12?5.60 fig and 0.8288?4.144 μg. The average recoveries of magnolol and iso-magnolol were 99.1% (RSD=1.64%) and 102.4% (RSD=1.67%).CONCLUSIONS The method is simple rapid and accurate. |
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| Keywords: | Xiangsha Yangwei pills magnolol isomagnolol HPLC |
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