肾通注射液对急性肾衰家兔内皮素和一氧化氮的影响

 目的：探讨活血化瘀药肾通注射液对急性肾衰家兔肾血管活性物质的影响。方法：健康雄性大耳白兔40只，随机平分为正常组、模型组、肾通治疗组和丹参治疗组，分别观测各组血肌酐（Scr）、尿素氮（BUN）、24h尿蛋白排泄率、滤过钠排泄分数（FENa）、内生肌酐清除率（Ccr）、血Na⁺、K⁺以及内皮素（ET）和一氧化氮（NO）水平，同时检测肾组织ET（NET）和NO（NNO）含量变化。结果：急性肾衰家兔经肾通、丹参注射液治疗后，肾功能各项指标均有显著改善（肾通效果似优于丹参，但两者无显著性差异），肾血管活性物质产生明显变化，血ET显著下降，NO水平升高，肾局部ET和NO与模型组比较差异更为显著。结论：肾通注射液对急性肾衰有防治作用，广泛调节肾血管活性物质，特别是对肾局部ET和NO的调节从而显著改善肾血流动力学是其重要的作用机理之一。

Influence of Shentong injection on the concentrations of endothelin and nitric oxide in plasma and kidney of rabbits with acute renal failure

OBJECTIVE To investigate the effects of activating microcirculation and removing blood stasis medicinal herbs-Shen-tong injection on the concentration of endothelin （ET）and nitric oxide（NO） in rabbits with acute renal failure（ARF）.METHODS Forty male rabbits were randomly divided into four groups: control group（N）、model group（M）、shentong injection treated group（T）and Danshen injection treated group（D）. Observe the effects of the injections to renal functional parameters, plasma and renal local endothelin and nitric oxide were measured respectively.RESULTS In Shentong injection treated group, all the renal functional parameters compared with model group were significantly different（all P<0.05）, plasma ET were decreased while NO in creased, the differences were significant in comparison with those in model group. The concentration of renal local ET and NO changes more obvious than that of plasma.CONCLUSIONS Shentong injection have certain effect in protecting kidney function from acute renal failure mainly through influence the changes of ET and NO, especially the content of renal local ET and NO.