| 川芎嗪对小鼠环磷酰胺损伤的保护作用 |
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| 引用本文： | 赵明宏,郭涛,宋洪涛,张晓虹,刘玉兰.川芎嗪对小鼠环磷酰胺损伤的保护作用[J].中国药学杂志,2002,22(12):717-718. |
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| 作者姓名： | 赵明宏 郭涛 宋洪涛 张晓虹 刘玉兰 |
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| 作者单位： | 1.沈阳军区总医院，辽宁沈阳110016；2.沈阳药科大学药学院，辽宁 沈阳 110016 |
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| 摘 要： | 目的：考察川芎嗪对小鼠环磷酰胺损伤的保护作用。方法：通过对小鼠灌胃给药川芎嗪，腹腔注射环磷酰胺，检测血 液白细胞、总蛋白、球蛋白水平以及心脏、脑、肝脏组织脂质过氧化物产物丙二醛含量。结果：川芎嗪能够抑制环磷酰胺对血 液中白细胞、总蛋白、球蛋白的降低，同时，与模型组比较，明显降低心脏、脑、肝脏组织丙二醛含量。结论：川芎嗪对小鼠环磷 酰胺损伤有一定保护作用。
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| 关 键 词： | 川芎嗪 白细胞 总蛋白 球蛋白 丙二醛 |
| 收稿时间： | 2002-01-10; |
Protective effect of tetramethyl pyrazine on cyclophosphamide injured mice |
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| ZHAO Ming-Hong,GUO Tao,SONG Hong-Tao,et al.Protective effect of tetramethyl pyrazine on cyclophosphamide injured mice[J].Chinese Pharmaceutical Journal,2002,22(12):717-718. |
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| Authors: | ZHAO Ming-Hong GUO Tao SONG Hong-Tao |
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| Institution: | Shenyang General Hospital of Military Region, Liaoning Shenyang 110016 |
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| Abstract: | OBJECTIVE To study the protective effect of tetramethyl pyrazine (TMP) on cyclophosphamide injured mice. METHODS The level of leucocyte, total protein, globulin and the content of malondial-hydride(MDA) produced by lipid peroxidatio in heart, liver, brain tissue were observed respectively. Cyclophosphamide was ip into mice pretreated with TMP. RESULTS TMP obviously inhibited the decrease of leucocyte, total protein, globulin protein and the content of MDA was decreased in heart, brain and liver tissue. CONCLUSIONS TMP protected the mice with cyclophosphamide from the injury. |
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| Keywords: | tetramethyl pyrazine(TMP) leucocyte total protein globulin malondial-hydride |
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