| 当归多糖对血瘀证动物免疫功能和抗氧化功能的影响 |
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| 引用本文： | 凌小曼,丁虹,罗顺德,张晓健,张连和.当归多糖对血瘀证动物免疫功能和抗氧化功能的影响[J].中国药学杂志,2002,22(10):584-586. |
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| 作者姓名： | 凌小曼 丁虹 罗顺德 张晓健 张连和 |
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| 作者单位： | 1．武汉大学医学院，湖北 武汉 430071；2.武汉大学药学院， 湖北 武汉 430072；3.湖北省消防总队医院，湖北 武汉 430022 |
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| 基金项目： | 湖北省自然基金项目，No 301130505 |
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| 摘 要： | 目的：研究当归多糖(angelica polysaccharide,ASP)对血瘀证大鼠的影响。方法：采用阿霉素造大鼠血瘀证模型，观察当归多糖对血瘀证动物免疫功能和抗氧化功能的作用。结果：当归多糖可明显改善血瘀证大鼠免疫功能, 其胸腺指数和脾脏指数明显升高，免疫球蛋白IgG、IgM、补体C5含量明显升高，升高心、脑、肾、胰四脏器超氧化物歧化酶(SOD)活性，降低心、脑、肾、胰四脏器丙二醛(MDA)含量（P<0.05或P<0.01）。结论：当归多糖具有抗氧化效应和免疫促进效应。
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| 关 键 词： | 当归多糖 胸腺指数 脾脏指数 免疫球蛋白 补体 超氧化物歧化酶(SOD) 丙二醛(MDA) |
| 收稿时间： | 2001-01-23; |
Study on the pharmacological mechanism of angelica polysaccharide on the immunocompetence and the effects of its anti-oxidation |
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| LING Xiao-Man,DING Hong,LUO Shun-De,et al.Study on the pharmacological mechanism of angelica polysaccharide on the immunocompetence and the effects of its anti-oxidation[J].Chinese Pharmaceutical Journal,2002,22(10):584-586. |
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| Authors: | LING Xiao-Man DING Hong LUO Shun-De |
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| Institution: | Medical College of Wuhan University, Hubei Wuhan 430071 |
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| Abstract: | OBJECTIVE To study the effects of angelica polysaccharide(ASP) on SD rats model with blood stasis.METHODS Blood stasis was established with adriamycin and treated with ASP. The results of ASP on the immunocompetence and its anti-oxidation effects were observed.RESULTS Those rats with blood stasis treated with ASP were shown an increased index of thymus,index of spleen, IgG,IgM,C5. The activities of SOD increased and the amounts of MDA from heart, brain, kidney and pancreas decreased obviously in treatment groups too（P<0.05 or P<0.01 ）.CONCLUSIONS ASP can improve the function of the immune system of SD rat model with blood stasis,it possesses anti-oxidation and immunocompetence effects. |
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| Keywords: | angelica polysaccharide (ASP) blood stasis index of thymus index of spleen SOD MDA |
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