| 雷公藤缓释片与雷公藤片治疗类风湿关节炎的对比 |
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| 引用本文： | 李瑞琳,吴旭初.雷公藤缓释片与雷公藤片治疗类风湿关节炎的对比[J].中国新药与临床杂志,1995(3). |
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| 作者姓名： | 李瑞琳 吴旭初 |
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| 作者单位： | 湖北省洪湖市中医医院，湖北中医学院附属医院 |
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| 摘 要： | 类风湿关节炎１２６例，采用随机单盲法分为２组。治疗组６４例（男性１８例，女性４６例；年龄４６±ｓ１３ａ）采用雷公藤缓释片（ＴＷ－ＳＲ）２片，ｐｏ，ｂｉｄ×４ｗｋ。对照组６２例（男性１８例，女性４４例；年龄４６±１５ａ）采用普通雷公藤片（ＴＷ）２片，ｐｏ，ｔｉｄ×４ｗｋ。结果：总有效率ＴＷ－ＳＲ组和ＴＷ组分别为９４％和９０％，不良反应发生率分别为９％和５６％（Ｐ＜０．０１），表明ＴＷ－ＳＲ优于ＴＷ。
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| 关 键 词： | 类风湿性关节炎，雷公藤，雷公藤内酯醇，迟效制剂 |
Sustained-release vs ordinary tablets of Tripterygium wilfordii in treating rheumatoid arthritis |
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| LI Rui-Lin.Sustained-release vs ordinary tablets of Tripterygium wilfordii in treating rheumatoid arthritis[J].Chinese Journal of New Drugs and Clinical Remedies,1995(3). |
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| Authors: | LI Rui-Lin |
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| Abstract: | One hundred and twenty-six patients with rheumatoid arthritis were randomly and single-blindly divided into two groups.Sustained-release tablets of Tripterygium wilfordii(Tw-SR)group including 64 patients(M18,F46; age46±s 13 a)received TW-SR tablets,2tablets(each tablet contains triptolide 49μg),po,bid for 4 wk.The other 62 patients(M 18,F 44;age 46±15a)received ordinary tablets of Tripterygium wilfordii(TW),2 tablets(each tablet contains triptolide 33 μg),po,tid for 4wk as control.Results showed that the total response rates in TW-SR and TW groups were 94% and 90%;adverse reactions were 9% and 56%(P< 0.01),respectively.It is concluded that TW-SR is superior to TW. |
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| Keywords: | rheumatoid arthritis Tripterygium wilfordii triptolide delayed-action preparations |
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