A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase |
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| Authors: | Chaturvedula V S Prakash Gao Zhijie Jones Shannon H Feng Xizhi Hecht Sidney M Kingston David G I |
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| Affiliation: | Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0212, USA. |
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| Abstract: | Bioassay-directed fractionation of a butanone extract of Monochaetum vulcanicum resulted in the isolation of a new triterpene (1) and four known compounds, ursolic acid (2), 2alpha-hydroxyursolic acid (3), 3-(p-coumaroyl)ursolic acid (4), and beta-sitosteryl-beta-d-galactoside (5). The structure of the new compound 1 was established as 3beta-acetoxy-2alpha-hydroxyurs-12-en-28-oic acid on the basis of extensive 1D and 2D NMR spectroscopic interpretation and chemical derivatization. Compounds 1-3 and 5 exhibited polymerase beta lyase activity. |
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