参麦注射液用于改善肝硬化失代偿期患者凝血功能临床观察

目的：观察参麦注射液用于改善肝硬化失代偿期患者凝血功能的效果。方法：将78例失代偿期肝硬化患者随机分为观察组和对照组各39例。对照组采用综合治疗，包括卧床、营养支持、维持水电解质酸碱平衡、护肝、降酶、退黄、抗病毒等治疗；观察组在此基础上给予20 ml参麦注射液加入5％葡萄糖注射液250 ml静脉滴注，1次/d，2组均治疗30天为1个疗程。分别于治疗前和疗程结束时测定患者凝血酶原时间（ PT）、活化部分凝血酶原时间（ APTT）和纤维蛋白原（ FIB）等凝血功能指标。结果：治疗前对照组PT、APTT和FIB分别为17．6±3．1秒、51．8±4．7秒、1．8±1．2g/L；治疗后对照组PT、APTT和FIB分别为16．1±3．3秒、47．2±5．1秒、1．9±1．4g/L；治疗前观察组PT、APTT和FIB分别为17．8±3．2秒5、2．1±4．9秒、1．7±1．1g/L；治疗后观察组PT、APTT和FIB分别为14．6±3．0秒、42．5±4．8秒、2．2±1．5g/L。治疗前2组患者PT、APTT和FIB指标均无统计学差异（P＞0．05）。同组患者治疗后上述指标均较治疗前改善，观察组改善程度比对照组更为显著（均P＜0．05）。结论：参麦注射液对于改善肝硬化失代偿期患者的凝血功能具有显著的临床效果。

Clinical Observation of Improvement of Coagulation Function in Patients with Decompensated Liver Cirrhosis Treated by Shenmai Injection

Objective：To observe the effects of improvement of coagulation function in patients with decompensated liver cirrhosis trea -ted by Shenmai injection .Methods：78 patients with decompensated liver cirrhosis were divided into observation group and control group with 39 patients each group .Control group were treated by comprehensive therapy such as stay in bed , nutrition support , keeping water , electrolyte and acid base balance , hepatic protection , decline the enzyme , removing jaundice , antiviral.Based on these , observation group were treated by Shenmai injection（20 ml Shenmai injection added into 250 ml 5%glucose injection ）, once a day.Two groups were treated for 30 days for a course of treatment.The PT , APTT, FIB were detected before and after treatment .Results：The PT, APTT, FIB in control group were （17.6 ±3.1）s、（51.8 ±4.7）s、（1.8 ±1.2）g/L respectively before treatment .After treatment, the PT , APTT, FIB in control group were（16.1 ±3.3）s、（47.2 ±5.1）s、（ 1.9 ±1.4）g/L respectively.The PT, APTT, FIB in observation group were （17.8 ±3.2）s、（52.1 ±4.9）s、 （1.7 ±1.1）g/L respectively .After treatment, the PT, APTT, FIB in observation group were （14.6 ± 3.0）s、（ 42.5 ±4.8）s、（2.2 ±1.5）g/L respectively.The differences of PT, APTT and FIB between two groups before treatment were no statistically significant（P〉0.05）.After treatment, the PT, APTT and FIB were improved, the improvement in observation group was bet-ter than control group （P〈0.05）.Conclusion：Shenmai injection has significant clinical effect on the improvement of coagulation function in patients with ddecompensated liver cirrhosis .