促红细胞生成素对大鼠慢性炎性贫血hepcidin mRNA表达的影响

目的探讨促红细胞生成素（EPO）在慢性炎性贫血（ACD）大鼠模型中对hepcidin mRNA表达的影响。方法通过反复注射弗氏完全佐剂，建立ACD大鼠动物模型。利用此模型比较药物干预组（EPO）与非干预组及正常对照组大鼠肝脏内hepcidin mRNA表达的差异与贫血的关系。结果ACD组hepcidin mRNA的表达显著增高，贫血明显；腹腔注射EPO后，hepcidin mRNA的表达降低，贫血改善。结论hepcidin可能参与了ACD的发生，EPO可能通过抑制炎症反应，减少炎症细胞因子的产生，从而抑制hepcidin mRNA表达来影响铁代谢治疗ACD，及早降低hepcidin水平，有利于阻止贫血的发展。为ACD的治疗提供一条新策略。

Preliminary report of expression of hepcidin gene in Wistar rats ACD model is affected by EPO

Objective To investigate the expression changes of the liver hepciding gene in the formation process of Wistar male rats anemia in chronic disease(ACD) model. Methods ACD rat model was established by repeated injection of Freund' s complete adjuvant. The relationship between hepcidin mRNA expression levels of normal rats, ACD rats and ACD rats after intra -peritoneal injection of EPO. Results Anemia was induced in the rat model. In the ACD group, hepcidin mRNA expression levels increased; after intra-peritoneal injection of EPO, hepcidin mRNA expression levels decreased, anemia is improved. Conclusion Hepcidin plays an important role in pathogenesis of ACD. EPO could be decreased hepcidin mRNA expression levels by anti- inflammatory reaction and decrease cell factors. Decrease of hepcidin level as early as possible will benefit to block the development of anemia, that will provide a new strategy of therapy for ACD.