白细胞介素16基因多态性与广西地区汉族女性膝关节原发性骨性关节炎的易感关联

背景:目前的基因研究表明,膝关节原发性骨性关节炎的发病风险与白细胞介素类基因有关联性.目的:观察白细胞介素16基因多态性与女性膝关节原发性骨性关节炎的相关性.方法:收集71例Kellgren/Lawrence评分大于2分的膝关节原发性骨性关节炎患者及85例健康对照的广西汉族女性的静脉血标本,采用聚合酶链反应-限制性片段长度多态性技术对两组白细胞介素16的 rs11556218,rs4072111,rs4778889多态位点进行基因分型,计算两组基因型和等位基因的分布差异,分析白细胞介素16基因多态性与膝骨性关节炎的易感关联.结果与结论:两组3个SNP位点的各基因频数在两组中的分布符合Hardy-Weinberg平衡,等位基因比较差异无显著性意义.单个位点显性模式非条件Logistic回归显示,在rs11556218的3种基因型的比较中,T/G基因型较T/T基因型的膝原发性骨性关节炎的发病风险显著减低(OR=0.41,95%CI:0.21~0.83,P=0.02);在rs4072111中,C/T基因型比C/C基因型的发病风险显著增加(OR=2.36,95%CI:1.19~4.68,P=0.03).结果证实,广西地区汉族女性人群白细胞介素16的遗传变异与膝关节原发性骨性关节炎的易感性关联.

Association of the interleukin-16 gene polymorphisms with primary knee osteoarthritis susceptibility in female population of Guangxi Zhuang Autonomous Region

BACKGROUND:Current genetic researches show that the risk factors for knee osteoarthritis(OA) mostly related to interleukin(IL) 1,6,10 and other interleukin genes.OBJECTIVE:To investigate whether the IL-16 gene polymorphisms is related to genetic susceptibility to primary OA in female.METHODS:Blood samples were obtained from 71 primary OA patients defined by a Kellgren-Lawrence score of 2 or greater,and 85 controls of Guangxi Han female population.The polymerase chain reaction-restriction fragment length pol...