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| 急性脊髓损伤模型大鼠与白细胞介素1受体拮抗剂的保护作用 | |
| 引用本文： | 黄颉刚,宗少晖,欧超,熊春翔,赵玉玺. 急性脊髓损伤模型大鼠与白细胞介素1受体拮抗剂的保护作用[J]. 中国组织工程研究与临床康复, 2011, 15(33): 6135-6138. DOI: 10.3969/j.issn.1673-8225.2011.33.014 |
| 作者姓名： | 黄颉刚 宗少晖 欧超 熊春翔 赵玉玺 |
| 作者单位： | 1. 广西医科大学,微生物学教研室,广西壮族自治区南宁市,530021 2. 广西医科大学,第一附属医院脊柱骨病外科,广西壮族自治区南宁市,530021 3. 广西医科大学,医学科学实验中心,广西壮族自治区南宁市,530021 |
| 基金项目： | 课题由广西医科大学博士启动基金,广西教育厅科研基金(桂教200710LX063)资助,名称:白细胞介素1,受体拮抗剂对急性脊髓损伤的组织学研究 |
| 摘 要： | 背景:白细胞介素1受体拮抗剂对大鼠急性脊髓损伤后脊髓功能修复具有保护作用,但具体机制不明。目的:观察白细胞介素1受体拮抗剂对大鼠急性脊髓损伤组织神经丝蛋白质200和胶质纤维酸性蛋白的影响。方法:SD大鼠随机分成假手术组,生理盐水对照组和白细胞介素1受体拮抗剂治疗组。采用改良Allen氏打击法建立急性脊髓损伤大鼠模型。分别在建模后1,48和72h获取损伤段8mm脊髓标本。结果和结论:免疫组织化学染色检测,白细胞介素1受体拮抗剂治疗组神经丝蛋白质200和胶质纤维酸性蛋白的表达较假手术组和生理盐水组高,差异有显著性意义(P<0.05)。提示白细胞介素1受体拮抗剂可使急性脊髓损伤大鼠模型损伤段脊髓神经丝蛋白质200和胶质纤维酸性蛋白表达增加,对急性脊髓损伤发挥保护作用。 |
| 关 键 词： | 急性脊髓损伤 白细胞介素1受体拮抗剂 神经丝蛋白质200 胶质纤维酸性蛋白 炎症反应 |
Effect of interleukin-1 receptor antagonist on neurofilament protein 200 and glial fibrillary acidic protein expression in a rat model of acute spinal cord injury |
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| Huang Jie-gang,Zong Shao-hui,Ou Chao,Xiong Chun-xiang,Zhao Yu-xi. Effect of interleukin-1 receptor antagonist on neurofilament protein 200 and glial fibrillary acidic protein expression in a rat model of acute spinal cord injury[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(33): 6135-6138. DOI: 10.3969/j.issn.1673-8225.2011.33.014 | |
| Authors: | Huang Jie-gang Zong Shao-hui Ou Chao Xiong Chun-xiang Zhao Yu-xi |
| Affiliation: | Huang Jie-gang1,Zong Shao-hui2,Ou Chao3,Xiong Chun-xiang2,Zhao Yu-xi2 1Department of Microbiology,2Department of Spine Surgery,First Affiliated Hospital of Guangxi Medical University,3Central Laboratory of Medical Sciences,Guangxi Medical University Nanning 530021,Guangxi Zhuang Autonomous Region,China. |
| Abstract: | BACKGROUND:Interleukin-1 receptor shows protective effects on spinal cord function recovery in rats with acute spinal cord injury,but the precise mechanism remains poorly understood.OBJECTIVE:To investigate the effect of interleukin-1 receptor antagonist(IL-1Ra)on neurofilament protein 200(NF 200)and glial fibrillary acidic protein(GFAP)expression in rat acute spinal cord injury tissue.METHODS:A total of 90 Sprague-Dawley rats were randomly divided into three groups:sham-operated,normal saline and IL-1Ra tr... |
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