| 聚乳酸-乙醇酸共聚物-磷酸三钙-骨形态发生蛋白2人工骨结合肌肉移植修复骨缺损 |
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| 引用本文： | 徐建强,周密,张树明,李长庚,杨飞,孙锁柱,王长江,王克利.聚乳酸-乙醇酸共聚物-磷酸三钙-骨形态发生蛋白2人工骨结合肌肉移植修复骨缺损[J].中国组织工程研究与临床康复,2011,15(34). |
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| 作者姓名： | 徐建强 周密 张树明 李长庚 杨飞 孙锁柱 王长江 王克利 |
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| 作者单位： | 解放军第二炮兵总医院骨科,北京市,100088 |
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| 基金项目： | 全军十五医药卫生科研基金(06G018)项目,课题名称:四肢战创伤大段骨缺损修复的系列研究 |
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| 摘 要： | 背景:大段骨缺损修复多以植骨为主,如果能将带血运的组织与人工骨同时植入,理论上更有利于新生组织血运建立及人工骨的爬行替代重建.目的:观察聚乳酸-乙醇酸共聚物-磷酸三钙-骨形态发生蛋白2人工骨结合自体带血供自体肌肉移植修复大段骨缺损的效果.方法:手术造成30 mm绵羊大段桡骨缺损,抽签随机分为3组:实验组植入聚乳酸-乙醇酸共聚物-磷酸三钙-骨形态发生蛋白2人工骨及自体带血运的屈指长肌,对照组仅植入聚乳酸-乙醇酸共聚物-磷酸三钙-骨形态发生蛋白2人工骨,空白对照组未植入任何材料.3组均以钢板固定骨缺损区,术后24周进行X射线检测及组织学观察.结果与结论:实验组桡骨缺损处完全成骨修复,皮质骨与髓腔轮廓清晰,骨痂为较成熟板层骨;对照组骨缺损基本完全修复,但新生骨密度及髓腔轮廓清晰度及骨痂成熟度均不如实验组;空白对照组无有效骨痂形成,缺损区被大量纤维组织填充.说明聚乳酸-乙醇酸共聚物-磷酸三钙-骨形态发生蛋白2人工骨结合自体带血供肌肉移植能够很好修复绵羊桡骨30 mm的大段骨缺损.
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| 关 键 词： | 骨形态发生蛋白2 聚乳酸-乙醇酸共聚物 磷酸三钙 肌肉移植 骨缺损 |
Polylactic-co-glycolic acid-tricalcium phosphate-bone morphogenetic protein-2 artificial bone combined with muscle transplantation for repair of bone defects |
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| Xu Jian-qiang,Zhou Mi,Zhang Shu-ming,Li Chang-geng,Yang Fei,Sun Suo-zhu,Wang Chang-jiang,Wang Ke-li.Polylactic-co-glycolic acid-tricalcium phosphate-bone morphogenetic protein-2 artificial bone combined with muscle transplantation for repair of bone defects[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(34). |
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| Authors: | Xu Jian-qiang Zhou Mi Zhang Shu-ming Li Chang-geng Yang Fei Sun Suo-zhu Wang Chang-jiang Wang Ke-li |
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| Institution: | Xu Jian-qiang,Zhou Mi,Zhang Shu-ming,Li Chang-geng,Yang Fei,Sun Suo-zhu,Wang Chang-jiang,Wang Ke-liDepartment of Orthopaedics,Second Artillery General Hospital of PLA,Beijing 100088,China Xu Jian-qiang,Doctor,Associate chief physician,Department of Orthopaedics,China |
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| Abstract: | BACKGROUND:Large segmental bone defects are mostly repaired by bone graft.If the tissue with blood life and artificial bone were simultaneously implanted into bone defects,which are theoretically more conducive to the construction of new tissue blood life and reconstruction of artificial bone creeping substitution.OBJECTIVE:To observe the effects of the composite of polylactic-co-glycolic acid-tricalcium phosphate-bone morphogenetic protein-2(PLGA-TCP-BMP-2) artificial bone combined with vascularized muscle... |
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