| 新西兰白兔非乙醇性脂肪性肝病模型的建立与评价 |
| |
| 引用本文： | 季榕,唐莉.新西兰白兔非乙醇性脂肪性肝病模型的建立与评价[J].中国组织工程研究与临床康复,2011,15(33):6124-6126. |
| |
| 作者姓名： | 季榕 唐莉 |
| |
| 作者单位： | 1. 新疆石河子大学医学院第一附属医院感染科,新疆维吾尔自治区石河子市,832008
2. 新疆医科大学第一附属医院感染科,新疆维吾尔自治区乌鲁木齐市,830054 |
| |
| 摘 要： | 背景:高脂饮食是导致非乙醇性脂肪性肝病发病的独立相关危险因素。目的:建立非乙醇性脂肪性肝病兔模型。方法:将新西兰白兔随机分为对照组和模型组,模型组给予高脂饮食,对照组给予普通动物饲料喂养。结果与结论:兔饲养12周后,模型组肝细胞均呈现弥漫性脂肪变性,汇管区与小叶间可见炎细胞浸润、坏死及纤维化,对照组肝脏无异常,且模型组肝指数、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、三酰甘油均高于对照组(P<0.01或P<0.05)。说明实验成功建立了非乙醇性脂肪性肝病兔模型。
|
| 关 键 词： | 脂肪性肝病 非乙醇性 新西兰白兔 动物模型 组织构建 |
Establishment and evaluation of nonalcoholic fatty liver disease model in New Zealand rabbits |
| |
| Ji Rong,Tang Li.Establishment and evaluation of nonalcoholic fatty liver disease model in New Zealand rabbits[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(33):6124-6126. |
| |
| Authors: | Ji Rong Tang Li |
| |
| Institution: | Ji Rong1,Tang Li2 1Department of Infectious Disease,First Affiliated Hospital of Medical School of Shihezi University,Shihezi 832008,Xinjiang Uygur Autonomous Region,China,2 Department of Infectious Disease,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054 |
| |
| Abstract: | BACKGROUND:Fat-rich diet is an independent risk factor of nonalcolholic fatty liver disease.OBJECTIVE:To establish a rabbit model of nonalcolholic fatty liver disease.METHODS:New Zealand rabbits were randomly divided into a control group and a model group.The model group rabbits were given fat-rich diet and the control group rabbits were given standard diet.RESULTS AND CONCLUSION:After raise for 12 weeks,hepatocytes of the model group rabbits developed diffuse fatty degeneration,inflammatory cell infiltrati... |
| |
| Keywords: | |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
