心理干预对造血干细胞采集亲缘供者心理状态的影响

目的探讨心理干预对造血干细胞亲缘供者心理状态的影响。方法将64例造血干细胞亲缘供者随机分为干预组（n=32）和对照组（n=32），对照组采用常规的术前健康教育，干预组在此基础上行心理干预。干预前后采用Zung抑郁自评量表（SDS）、焦虑自评量表（SAS）对两组供者的心理状态进行评分，同时记录两组供者的心率、血压并进行相关分析。结果干预组血压、心率与干预前比较差异无统计学意义（P〉0．05），与对照组比较差异均有统计学意义（P〈0．01）。干预组抑郁、焦虑得分与干预前比较均下降（P〈0．05），与对照组比较差异均有统计学意义（P〈0．05）。结论对造血干细胞亲缘供者实施心理干预，可减轻其焦虑、抑郁心理和维持血压、心率的稳定。

Effect of psychological intervention on the mental state of related donors for allogeneic hematopoietic stem-cell transplantation(HSCT)

Objective To explore the impact of psychological intervention on the mental state of related donors for allogeneic hematopoietic stem-cell transplantation(HSCT). Methods 64 donors for HSCT were randomly divided into intervention and control groups (32 cases for each group). Routine preoperative health education was given to the donors in the control group and psychological intervention was adopted in the intervention group on the basis of routine health education. Zung self-rating depression scale (SDS) and self-rating anxiety scale (SAS)were used to mark the scores of the mental state of donors in both groups and heart rate, blood pressure of the donors were recorded and analyzed before and after intervention. Results Compared with those before intervention, there were no statistically significant differences in blood pressure and heart rate of the donors in the intervention group (P ＞ 0. 05); the differences were statistically significant in the comparison of blood pressure and heart rate of the donors between the two groups (P ＜ 0. 05). The scores of depression and anxiety decreased compared with those before intervention in the intervention group (P ＜ 0. 05), and the differences in the comparison of the scores were statistically significant between the two groups (P ＜ 0. 05). Conclusions Psychological intervention is the key to reduce anxiety and depression and stabilize blood pressure and heart rate of the related donors for allogeneic hematopoietic stem-cell transplantation.