| 同种异体肢体移植中他克莫司的应用剂量 |
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| 引用本文： | 尚剑,刘伟,韩昕光,凌晓东,苏俭.同种异体肢体移植中他克莫司的应用剂量[J].中国组织工程研究与临床康复,2011,15(31). |
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| 作者姓名： | 尚剑 刘伟 韩昕光 凌晓东 苏俭 |
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| 作者单位： | 哈尔滨医科大学第一附属医院骨科,黑龙江省哈尔滨市,150001 |
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| 基金项目： | 黑龙江教育厅科学技术研究项目 |
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| 摘 要： | 背景:他克莫司应用于同种异体肝移植的免疫耐受已多见报道.目的:探索他克莫司在异体肢体移植时的最佳应用剂量.方法:建立同种异体肢体移植大鼠模型,移植造模后设立给予不同他克莫司剂量的0.5,1,2 mg/(kg?d)组及对照组,对大鼠进行大体观察、组织学、淋巴细胞亚群测定.结果与结论:移植后出现排斥反应的时间分别是对照组(3.43±0.79) d、0.5 mg/(kg?d)组(5.68±0.97) d、1 mg/(kg?d)组(9.13±1.17) d、2 mg/(kg?d) 组(9.61±2.38) d,排斥反应的病理分级4组分别为(2.61±0.38),(1.57±0.43),(0.85±0.24),(0.71±0.19)级.移植后各给药组CD4+、CD8+检测值均明显下降,CD4/CD8比值轻度增加或在正常值范围内;对照组CD4+、CD8+无明显变化,CD4/CD8比值明显增加.提示,他克莫司的应用剂量在1 mg/(kg?d)时就能达到理想的抑制免疫排斥反应,提高用量后意义不大.
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| 关 键 词： | 他克莫司 同种异体肢体移植 造模 剂量 排斥反应 |
Tacrolimus application dose in limb allograft transplantation |
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| Shang Jian,Liu Wei,Han Xin-guang,Ling Xiao-dong,Su Jian.Tacrolimus application dose in limb allograft transplantation[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(31). |
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| Authors: | Shang Jian Liu Wei Han Xin-guang Ling Xiao-dong Su Jian |
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| Institution: | Shang Jian,Liu Wei,Han Xin-guang,Ling Xiao-dong,Su Jian Department of Orthopedics,First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China |
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| Abstract: | BACKGROUND:Tacrolimus (FK506) is widely used in human organ transplantation and prolongs allograft survival in several animal models, yet there is still no consistent standard in current clinical application. OBJECTIVE:To investigate the optimal application dose of FK506 in limb allograft rats. METHODS:Sixty rat models of hind limb allograft were randomly divided into three groups (A, B and C) and daily received FK506 0.5, 1, and 2 mg/kg respectively. Twenty untreated allograft rats served as the control gr... |
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