| 左卡尼汀强化St.Thomas No.2液对低温离体心脏的保存效果 |
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| 引用本文： | 周涛,张大国,向道康.左卡尼汀强化St.Thomas No.2液对低温离体心脏的保存效果[J].中国组织工程研究与临床康复,2011,15(31). |
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| 作者姓名： | 周涛 张大国 向道康 |
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| 作者单位： | 贵州省人民医院,贵州省心血管病医院心外科,贵州省贵阳市,550002 |
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| 基金项目： | 贵州省科技攻关资助项目 |
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| 摘 要： | 背景:在心脏瓣膜置换中应用添加左卡尼汀的心脏停搏液可明显减轻心肌线粒体的脂质过氧化反应,保护心肌细胞.目的:观察加入左卡尼汀的St.Thomas No.2液对大鼠离体心脏低温保存的效果.方法:利用Langendorff 灌注装置建立SD大鼠离体心脏灌注和工作模型,随机分成4组,其中2组采用 St.Thomas No.2 液作为心脏停搏液与保存液分别保存心脏4 h、6 h,另2组采用添加左卡尼汀的St.Thomas No.2液作为心脏停搏液与保存液分别保存心脏4 h、6 h.结果与结论:与St.Thomas No.2 液保存4 h组比较,添加左卡尼汀的St.Thomas No.2液保存 4 h组心脏心率、冠状动脉流量、左心室收缩峰压和左心室内最大上升速率及心肌含水量、ATP含量差别无显著性意义(P > 0.05),但心肌酶漏出量明显减少(P < 0.05);添加左卡尼汀的St.Thomas No.2液保存 6 h组上述指标检测结果均优于St.Thomas No.2保存6 h组 (P < 0.05).提示左卡尼汀强化的St.Thomas No.2液可显著提高大鼠离体心脏的低温保存效果.
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| 关 键 词： | 左卡尼汀 心麻痹液 器官保存液 心脏移植 离体 |
Protective effects of St.Thomas No.2 solution supplemented with levocarnitine on preservation of hypothermic heart ex vivo |
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| Zhou Tao,Zhang Da-guo,Xiang Dao-kang.Protective effects of St.Thomas No.2 solution supplemented with levocarnitine on preservation of hypothermic heart ex vivo[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(31). |
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| Authors: | Zhou Tao Zhang Da-guo Xiang Dao-kang |
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| Abstract: | BACKGROUND:On-pump beating-heart technique has been promoted as better systemic protection compared with the technique of cardioplegic arrest, and the attenuated inflammatory reaction may play an important role in the protective effect of the on-pump beating-heart technique. OBJECTIVE:To observe the protective effects of St. Thomas No.2 solution supplemented with levocarnitine on preservation of hypothermic rat hearts ex vivo. METHODS:Isolated rat heart Langendorff model and working model were established. ... |
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