| 去神经支配骨骼肌萎缩的多种治疗 |
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| 引用本文： | 陈波,陈振兵,杜远立.去神经支配骨骼肌萎缩的多种治疗[J].中国组织工程研究与临床康复,2011,15(37). |
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| 作者姓名： | 陈波 陈振兵 杜远立 |
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| 作者单位： | 1. 三峡大学人民医院骨科,湖北省宜昌市,443000
2. 华中科技大学同济医学院协和医院手外科,湖北省武汉市,430022 |
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| 摘 要： | 背景:骨骼肌去神经支配后出现肌萎缩和收缩功能的丧失,肌纤维发生与萎缩相关的一系列的形态学和组织学的变化.近年来随着技术水平及理论研究的进展,治疗效果有了较大的提高,但仍未达到满意的效果.目的:总结并讨论近年来有关去神经支配骨骼肌萎缩的治疗新进展,为肌肉功能的恢复提供理论基础.方法:由第一作者用计算机检索中国期刊全文数据库(CNKI:2000/2010)和Medline数据库(2000/2010),检索词分别为"去神经支配,骨骼肌,肌萎缩,治疗"和"denervated,skeletal muscles,atrophy,treatment".共检索到135篇文章,按纳入和排除标准对文献进行筛选,共纳入30篇文章,从物理治疗、神经修复和植入、细胞移植、药物、基因和中药治疗等方面进行总结和分析.结果与结论:近年来去神经支配骨骼肌的治疗取得了很大进展,但这些方法只能在一定程度上缓解骨骼肌萎缩,在一段时间内维持肌肉的生理功能.目前研究随着去神经支配骨骼肌萎缩机制的阐明,针对性的治疗措施将会取得更好的效果.
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| 关 键 词： | 去神经支配 骨骼肌 肌萎缩 治疗 组织工程 |
Multiple treatments for denervated skeletal muscle atrophy |
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| Chen Bo,Chen Zhen-bing,Du Yuan-li.Multiple treatments for denervated skeletal muscle atrophy[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(37). |
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| Authors: | Chen Bo Chen Zhen-bing Du Yuan-li |
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| Institution: | Chen Bo1,Chen Zhen-bing2,Du Yuan-li1 1Department of Orthopedics,People's Hospital of China Three Gorges University,Yichang 443000,Hubei Province,China,2Department of Hand Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022 |
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| Abstract: | BACKGROUND:Following denervation, the loss of contractile function and amyotrophy occur in skeletal muscle, and myofibers show a series of histomorphological changes concerning amyotrophy. With progress in technical levels and theory research, considerable improvement in the treatment effects have been achieved, but it is not satisfactory. OBJECTIVE:To summarize and discuss the recent progress in treatment methods of denervated skeletal muscles atrophy and provide theoretical evidence for recovery of muscle... |
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| 本文献已被 CNKI 万方数据 等数据库收录！ |
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