羟基磷灰石涂层的钛-75合金种植体的犬骨内种植实验

目的：观察评体羟基磷灰石（ＨＡ）烧结涂层的钛０７５（Ｔｉ－７５）合金种植体（ＨＡＴＩ）的生物学性能与生物力学特性。方法：应用穿皮质骨种植模型，以纯钛种植体（ＰＴＩ）作对照，在双侧犬股骨内种植ＨＡＴＩ和ＰＴＩ共３２ 术后３个月和６个月处死动物取村。应用组织学、定量组织学、推出试验、扫描电镜等方法，观察种植体骨界面的结合情况和剪切强度。结果：ＨＡＴＩ与ＰＴＩ均与骨组织形成了骨性结合，ＨＡＴＩ的骨性结合

Experimental study of hydroxyapatite coated Ti-75 alloy implant in dogs

Objective: To evaluate the biocompatibility and bio mechanical of HA sintering coated Ti 75 alloy implant (HATI). Methods: A transcortical implant model was used. A total of 32 implants of HATI and pure titanium implant (PTI) were implanted into bilateral femur of 4 adult mongrel dogs. The animals were killed 3 or 6 months after surgery. The implant bone interfaces were observed by X ray examination, morphological and quantitative histological examination. The shear strength at implant bone interface was examined by push out test, and the failure interfaces were observed by SEM. Results: Osseo intergration was confirmed in the both interfaces of HATI and PTI with bone. The osseo intergration rate and shear strength of HATI were greater than that of PTI at the same period( P <0.01). After 6 months, the shear strength of HATI reached 12.76 MPa, SEM showed the major failure at interfaces of coating bone and within the coating. Conclusion: The results of this study indicate that HATI is biocompatible and has better biomechanics. The HATI is worth further investigating and could be recommended for clinical applications.