| 1型糖尿病患者外周血中CD4^＋CD25^＋与CD8^＋CD28^-调节性T细胞水平的研究 |
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| 引用本文： | 叶学和,覃锦耀,梁深,劳丹华,黄庆娟. 1型糖尿病患者外周血中CD4^＋CD25^＋与CD8^＋CD28^-调节性T细胞水平的研究[J]. 中华糖尿病杂志, 2009, 17(6): 473-474 |
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| 作者姓名： | 叶学和 覃锦耀 梁深 劳丹华 黄庆娟 |
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| 作者单位： | 叶学和,梁深,劳丹华,黄庆娟(钦州市第一人民医院内分泌科,广西,535000);覃锦耀(广西医科大学第一附属医院检验科) |
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| 摘 要： | 流式细胞仪检测1型糖尿病（T1DM）患者外周血CD4^＋CD25^＋与CD8^＋CD28^-调节性T细胞的水平，发现其外周血CD4^＋CD25^＋T淋巴细胞水平[（2．02±0．43）％]显著低于2型糖尿病（T2DM）组[（6．79±1．75）％]和健康对照（NC）组[（7．84±1．45）％]，而CD8^＋CD28^-调节性T细胞水平三组间无差异。
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| 关 键 词： | 糖尿病 1型 CD8^+ CD28^- CD4^+ CD25^+ 调节性T细胞 |
Study on the levels of CD4+CD25+ and CD8+CD28- regulatory T cell in the peripheral blood of patients with type 1 diabetes mellitus |
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| Affiliation: | YE Xue-he,QIN Jin-yao,LIANG Shen,et al. (First People＇ s Hospital of Qinzhou City, Guangxi 535000, China) |
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| Abstract: | Flow cytometry were used to investigate the levels of CD4^＋ CD25^＋ and CD8^＋ CD28^- regulator T cells in the peripheral blood of patients with type 1 diabetes mellitus. The percent of CD4^＋ CD25^＋ T lymphocytes of TIDM [（2.02±0. 43）%] was remarkably lower than that of type 2 diabetes mellitus [（6.79±1.75）%] and controls [（7. 84±1.45）%. The levels of CD8^＋ CD28^- regulator lymphocyte among three groups were not different. The level of CD4^＋ CD25^＋ regulatory T cell in T1DM patients shows low expression. |
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| Keywords: | CD8 CD28- CD4 CD25 |
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