| 普乐可复与环孢素A对肾移植患者血脂影响的临床研究 |
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| 引用本文： | 王伟刚,傅耀文,周洪澜,高宝山,李萍.普乐可复与环孢素A对肾移植患者血脂影响的临床研究[J].中国实验诊断学,2006,10(6):631-632. |
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| 作者姓名： | 王伟刚 傅耀文 周洪澜 高宝山 李萍 |
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| 作者单位： | 1. 吉林大学中日联谊医院,泌尿外科,吉林,长春,130033
2. 吉林大学中日联谊医院,肾内科,吉林,长春,130033 |
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| 摘 要： | 目的比较普乐可复（FK506）与环孢素A（CsA）对肾移植术后病人血脂的影响。方法132例肾移植术后病人随机分为普乐可复组（n=67）和环孢素A组（n=85），术后随访2年，对比两组甘油三脂及总胆固醇水平。结果除术后6个月以外，其余时间点（术后1个月、3个月、1年和2年）FK506组的甘油三脂和总胆固醇水平均较CsA组低，且差异具有显著性（P〈0．05）。结论肾移植术后病人应用FK506与CsA相比，高脂血症的发病率明显降低。
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| 关 键 词： | 普乐可复 环孢素A 血脂 肾移植 |
| 文章编号： | 1007-4287（2006）06-0631-02 |
| 收稿时间： | 2005-08-15 |
| 修稿时间： | 2005年8月15日 |
Clinical study on the effects of serum lipids between FK506 and cyclosporin A in renal allograft recipient |
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| WANG Wei, FU Yao- wen , ZHO U Hong- lan ,et al..Clinical study on the effects of serum lipids between FK506 and cyclosporin A in renal allograft recipient[J].Chinese Journal of Laboratory Diagnosis,2006,10(6):631-632. |
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| Authors: | WANG Wei FU Yao- wen ZHO U Hong- lan |
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| Institution: | WANG Wei, FU Yao- wen , ZHO U Hong- lan , et al. |
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| Abstract: | Objective To compare the effects of serum lipids between FK506 and Cs in renal allograft recipients.Methods 132 cases of renal recipients were involved in this study,among them 67 on FK506 treatment and 85 on CsA treatment.Changes of serum lipids were observed in the follow-up for two years after transplantation.Results No signifinant differentce of the serum lipids mean levels was found between the two groups before operation(P>0.05).Serum cholesterol and triglyceride in CsA group was significantly higher than that of FK506 group after operation.Conclusion FK506 is superior to CsA with respect to their effect on serum lipids. |
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| Keywords: | FK506 CsA serum lipids renal transplantation |
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