| K-ras基因在人喉鳞状细胞癌细胞株(Hep-2)中的表达及其意义 |
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| 作者姓名： | CHEN Xiong KONG Weijia ZHANG Sulin ZHANG Dan |
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| 作者单位： | Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| 基金项目： | This work was supported by a grant from the National Natural Science Foundation of China （No. 30070809）. |
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| 摘 要： | Objective： To investigate the expression of K-ras in human laryngeal squamous cell carcinoma cell lines （Hep-2） and its significance for establishing a solid foundation for further study of the relationship between human laryngeal squamous cell carcinoma and K-ras gene point mutations. Methods： The expression of K-ras in human laryngeal squamous cell carcinoma cell lines （Hep-2） and human pancreatic carcinoma cell lines （MIAPaCa-2） was detected by using RT-PCR. Results： The expression of K-ras mRNA in Hep-2 and MIAPaCa-2 was strong and positive. Conclusion： The expression of K-ras mRNA in human laryngeal squamous cell carcinoma cell lines （Hep-2） is positive. Development of laryngeal carcinoma might be related to the activation of K-ras gene point mutation.
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| 关 键 词： | K-ras细胞 Hep-2细胞 基因表达 喉部肿瘤 |
| 收稿时间： | 2005-04-03 |
| 修稿时间： | 2005-05-10 |
Relation between the Expression of K-ras in Hep-2 Cells and
Development of Laryngeal Carcinoma |
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| CHEN Xiong KONG Weijia ZHANG Sulin ZHANG Dan.Relation between the Expression of K-ras in Hep-2 Cells and
Development of Laryngeal Carcinoma[J].The Chinese-German Journal of Clinical Oncology,2006,5(1):18-19. |
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| Authors: | Xiong CHEN Weijia KONG Sulin ZHANG Dan ZHANG |
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| Institution: | (1) Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China |
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| Abstract: | Objective: To investigate the expression of K-ras in human laryngeal squamous cell carcinoma
cell lines (Hep-2) and its significance for establishing a solid foundation for further study of the relationship
between human laryngeal squamous cell carcinoma and K-ras gene point mutations. Methods:
The expression of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and human pancreatic
carcinoma cell lines (MIAPaCa-2) was detected by using RT-PCR. Results: The expression of
K-ras mRNA in Hep-2 and MIAPaCa-2 was strong and positive. Conclusion: The expression of K-ras
mRNA in human laryngeal squamous cell carcinoma cell lines (Hep-2) is positive. Development of laryngeal
carcinoma might be related to the activation of K-ras gene point mutation. |
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| Keywords: | K-ras human laryngeal squamous cell carcinoma cell lines (Hep-2) RT-PCR |
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