2种胰岛素用于胰岛素泵对2型糖尿病患者短期强化治疗的临床疗效研究

目的比较胰岛素类似物（诺和锐）与人胰岛素（诺和灵R）分别应用于胰岛素泵对2型糖尿病患者短期强化治疗的临床疗效差异。方法 58例住院需胰岛素治疗的2型糖尿病患者随机分为2组：诺和锐组和诺和灵R组,胰岛素泵治疗2周,比较2组患者治疗过程中每日3餐前后和睡前血糖,血糖达标所需天数及胰岛素用量。结果 3餐前和睡前血糖下降,2组间差异无显著性（P〉0.05）。诺和锐组FBG、PBG 2 h及全天血糖控制达标时间均短于诺和灵R组（P〈0.01）,餐后血糖指标好于诺和灵R组（P〈0.05）,胰岛素用量低于诺和灵R组（P〈0.05）。结论用胰岛素泵输注诺和锐及诺和灵R均能使2型糖尿病患者高血糖状态得到良好控制,但诺和锐对餐后血糖控制更理想,血糖控制达标所需时间更短,所需胰岛素量更少。

Clinical effect of 2 insulin preparations in short-term intensive therapy of type 2 diabetic patients with insulin pump

Objective To compare the clinical effect of insulin aspart and novolin R with insulin pump in short-term intensive therapy for type 2 diabetic patients.Methods A total of 58 patients with type 2 diabetes who had poorly controlled blood glucose were randomly divided into 2 groups to undergo insulin pump therapy with aspart or novolin R for 2 weeks.The change of blood glucose（include before and after 3 meals and bedtime）,the time and the dose of insulin needed for good glycemia control were compared between the 2 groups.Results No significant differences in the blood glucose between the 2 groups were observed in bedtime and before 3 meals（P0.05）.The time for good glycemia control was shorter in the insulin aspart group than in novolin R group（P0.01）,while the postprandial blood glucose after 3 meals mean dose of insulin and the frequency of hypoglycemia in the aspart group were significantly lower in the aspart group than in the novolin R group（P0.05）.Conclusion Insulin aspart via insulin pump is as effective as novolin R in controlling hyperglycemia in type 2 diabetes,but insulin aspart provides more effective and faster control of postprandial hyperglycemia with less insulin.