| 人类Y染色体微缺失与精子生成障碍的研究进展 |
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| 引用本文： | 贾咏存,魏莎莉. 人类Y染色体微缺失与精子生成障碍的研究进展[J]. 国际遗传学杂志, 2006, 29(4): 273-276. DOI: 10.3760/cma.j.issn.1673-4386.2008.06.002 |
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| 作者姓名： | 贾咏存 魏莎莉 |
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| 作者单位： | 400016,重庆医科大学公共卫生学院;400016,重庆医科大学公共卫生学院 |
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| 摘 要： | 本文就人类Y染色体的结构及其与精子生成相关的主要功能基因的研究进展作了综述，重点对AZF区的USP9Y.RBM. DAZ. CDY等基因的缺失与精子生成障碍的关系进行了探讨。为临床实施辅助生育技术治疗前对精子质量的筛查.无精症患者的诊断及遗传咨询提供理论依据。
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| 关 键 词： | Y染色体 AZF区 微缺失 精子生成障碍 |
| 收稿时间： | 2005-05-30 |
| 修稿时间： | 2005-05-30 |
Advance in the Research of the Human Y Chromosome Microdeletion and Spermatogenic Failure |
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| JIA Yong-cun,WEI Sha-li. Advance in the Research of the Human Y Chromosome Microdeletion and Spermatogenic Failure[J]. International JOurnal of Genetics, 2006, 29(4): 273-276. DOI: 10.3760/cma.j.issn.1673-4386.2008.06.002 |
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| Authors: | JIA Yong-cun WEI Sha-li |
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| Affiliation: | School of Public Health, Chongqing University of Medical Sciences, Chongqing 400016, P. R. China |
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| Abstract: | The article expounds the structure of the human Y chromosome and it's main functional gene that correlates with spermatogenesis,chiefly discuss the deletion of each gene in AZF region such as USP9Y,RBM,DAZ,CDY with spermatogenic failure.These findings provide a theoretical basis for clinical di- agnosis of azoospermic patients and genetic consultation. |
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| Keywords: | Y chromosome AZF region Microdeletion Spermatogenic failure |
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