| 上皮性卵巢癌P16蛋白表达的研究 |
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| 引用本文： | 王瑞,吴宜林. 上皮性卵巢癌P16蛋白表达的研究[J]. 中国现代医学杂志, 2003, 13(3): 13-14 |
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| 作者姓名： | 王瑞 吴宜林 |
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| 作者单位： | 1. 山西省太原市中心医院
2. 中南大学湘雅二医院,长沙,410011 |
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| 摘 要： | 目的：探讨P6基因蛋白表达与上皮性卵巢病发生、发展的关系。方法：应用SP免疫组织化学方法对13例正常卵巢，17例良性卵巢肿瘤和40例上皮性卵巢癌P6蛋白表达进行检测。结果：P16蛋白在正常卵巢、良性卵巢肿瘤及上皮性卵巢癌中阳性表达率分别为57．69％，41．18％，67．5％。各组间无显著性差异(P＞0．05)。上皮性卵巢癌P6蛋白表达强度与组织学类型，病理分级及临床分期有关。组织分化越差，临床期别越高，P6表达越弱。结论：P6蛋白表达异常在上皮性卵巢癌发生、发展中起一定作用。
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| 关 键 词： | 上皮性卵巢癌 P16蛋白 基因表达 免疫组织化学 研究 |
| 修稿时间： | 2002-12-18 |
EXPRESSION OF P16 PROTEIN IN EPITHELIAL OVARIAN CANCER |
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| Wang Rui,Wu Yilin The Second Xiangya Hospital,Central South University,Changsha $$$$. EXPRESSION OF P16 PROTEIN IN EPITHELIAL OVARIAN CANCER[J]. China Journal of Modern Medicine, 2003, 13(3): 13-14 |
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| Authors: | Wang Rui Wu Yilin The Second Xiangya Hospital Central South University Changsha $$$$ |
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| Affiliation: | Wang Rui,Wu Yilin The Second Xiangya Hospital,Central South University,Changsha 410011$$$$ |
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| Abstract: | Objective:To explore the relationship between expression of P16 protein and development of epithelial ovarian cancers. Method:The expression of P16 was detected in 13 cases of normal ovaries, 17 cases of benign tumors and 40 cases of epithelial ovarian cancers by immunohistochemistry (S-P method). Results:The positive rate of P16 protein in expression was 57.69% in normal ovaries, 41.18% in benign tumors and 67.5% in epithelial ovarian cancers.There was no significant difference among these groups ( P >0.05). The expression of P16 protein was correlated with its histological types, clinical stage and histologic grade. The lower expression of P16 protein was associated with advanced stage and grade. Conclusion:There was a certain correlation between the expression of P16 and development of epithelial ovarian cancers. |
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| Keywords: | Epithelial Ovarian Cancer P16 Protein Immunohistochemistry |
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