急性脑血栓形成患者血浆及脑脊液纤溶指标的观察

目的：研究急性脑血栓形成患者血浆及脑脊液组织型纤溶酶原激活物(t-PA)及其抑制物(PAI-1)和D-二聚体含量的变化及其临床意义。方法：采用双抗体夹心固相酶联免疫吸附法(ELISA)检测35例急性脑血栓形成患者(血栓组)的血浆和其中3l例的脑脊液t—PA、PAI-l和D-二聚体的抗原含量，与35例无心脑、肝肾及血液疾病患者(对照组)血浆和其中20例脑脊液进行比较。结果：血栓组血浆及脑脊液中t-PA、PAI-1和D-二聚体含量均高于对照组；脑脊液中t-PA、PAI-l和D-二聚体的含量分别与血浆中含量呈正相关。结论：急性脑血栓形成患者纤溶活性明显下降,t-PA及PAI-l参与了脑血栓形成的病理过程。

Fibrinolytic Activity in Plasma and Cerebrospinal Fluid in Patients with Acute Cerebral Thrombosis

Objective: To observe the changes in contents of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) and D-dimer antigen in plasma and cerebrospinal fluid from patients with acute cerebral thrombosis respectively and clinical significance. Methods: Plasma contents of t-PA,PAI-1 and D-dimer antigen were determined in 35 patients with acute cerebral thrombosis and in 35 normal control subjects, and cerebrospinal fluid contents of t-PA,PAI-1 and D-dimer antigen were also determined in 31 patients with acute cerebral thrombosis and in 20 normal control subjects. Results:In acute cerebral thrombotic group, the plasma contents of t-PA antigen in patients were higher than those of normal control subjects ( P <0.05); the plasma contents of PAI-1 and D-dimer antigen were significantly higher ( P <0.01). The cerebrospinal fluid contents of t-PA,PAI-1 and D-dimer antigen in the patients with acute cerebral thrombosis were significantly higher than those of normal control subjects; They were positively correlated with plasma contents of t-PA,PAI-1 and D-dimer antigen. Conclusion:The fibrinolytic activity in the patients with acute cerebral thrombosis was significantly lower than normal controls. It suggests that the plasma t-PA, PA-1 and D-dimer might play a role in the pathogenesis of cerebral thrombosis.