| 养肝利胆颗粒对胆色素结石炎症反应环节的影响 |
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| 引用本文： | 梁晓强,章学林,顾宏刚,张静喆.养肝利胆颗粒对胆色素结石炎症反应环节的影响[J].中国中西医结合消化杂志,2009,17(2):102-104. |
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| 作者姓名： | 梁晓强 章学林 顾宏刚 张静喆 |
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| 作者单位： | 1. 上海中医药大学附属龙华医院,中医外科研究所,上海,200032
2. 上海中医药大学附属龙华医院,普外科,上海,200032 |
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| 基金项目： | 上海市重点学科资助课题，上海市医学领军人才资助课题，上海市教育委员会科研创新项目 |
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| 摘 要： | 目的]观察养肝利胆颗粒（YGLD）对豚鼠胆色素结石形成过程中炎症环节的影响。方法]应用雄性豚鼠皮下注射林可霉素联合喂养致石饲料建立胆色素结石模型，观察YGLD对该模型成石率、胆囊容积、胆汁中黏蛋白及C反应蛋白（CRP）浓度的影响。结果]YGLD组与模型组比较成石率显著降低（P〈0．01），胆囊容积明显减小（P〈0．05），胆汁中黏蛋白及CRP浓度明显降低（P〈0．05）。结论]YGLD通过降低胆汁中黏蛋白、CRP水平来发挥逆转成石胆汁及降低胆色素结石成石率的重要作用。
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| 关 键 词： | 养肝利胆颗粒 胆色素结石 豚鼠 |
Effects of Yangganlidan Granule on inflammatory reaction in model guinea-pigs with pigment gallstones |
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| LIANG Xiao-qiang,ZHANG Xue-lin,GU Hong-gang,ZHANG Jing-zhe.Effects of Yangganlidan Granule on inflammatory reaction in model guinea-pigs with pigment gallstones[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2009,17(2):102-104. |
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| Authors: | LIANG Xiao-qiang ZHANG Xue-lin GU Hong-gang ZHANG Jing-zhe |
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| Affiliation: | LIANG Xiao-qiang, ZHANG Xue-lin, GU Hong-gang, ZHANG Jing-zhe (1 Institute of Chinese Traditional Surgery, I_onghua hospital , Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; 2 Department of General Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China) |
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| Abstract: | Objective]To observe the effects of Yangganlidan granule （YGLD） on inflammato- ry reaction in model guinea-pigs with pigment gallstones. Methods] Animal model of pigment gallstones was reproduced in male guinea pigs by hypodermic injection of lincomycin. And then the rate of stone formation, gallbladder volume, muein and C-reactive protein in bile were observed among three groups. Results]Compared to model group, the rates of stone formation in YGLD group were significantly decreased（P〈0. 01）, and gallbladder volume in YGLD group was significantly decreased（P〈0. 05）. Meanwhile mucin and C-reactive protein content of bile in YGLD group was also significantly decreased（P〈0. 05）. Conclusion]YGLD has good effects on inflammatory reaction in model guinea-pigs with pigment gallstones in reversing the lithogenesity of bile by reducing the content of mucin and C-reactive protein in bile. |
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| Keywords: | Yangganlidan granule （YGLD） pigment gallstones guinea-pigs |
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