| 正交试验法优化葡萄籽软胶囊的制备处方 |
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| 引用本文： | 李绪发,唐秀芳,李建英.正交试验法优化葡萄籽软胶囊的制备处方[J].北方药学,2014,0(3):47-48. |
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| 作者姓名： | 李绪发 唐秀芳 李建英 |
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| 作者单位： | 广东省仙乐制药有限公司 汕头 515041;广东省仙乐制药有限公司 汕头 515041;广东省仙乐制药有限公司 汕头 515041 |
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| 摘 要： | 以大豆油为分散介质,蜂蜡为助悬剂,大豆磷脂为润湿剂,以沉降比和再分散性为指标,采用正交设计优化葡萄籽软胶囊的填充物处方。结果表明：葡萄籽软胶囊的填充物最佳配比为葡萄籽提取物-大豆油-蜂蜡-大豆磷脂（18.2∶72.8∶6∶3）,制备得到的软胶囊填充物料液均匀、稳定、流动性好。
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| 关 键 词： | 葡萄籽 软胶囊 正交试验 填充物 |
Optimization of Grape Seed Extract Soft Capsule Preparation by Orthogonal Experiment |
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| Li Xufa Tang Xiufang Li Jianying.Optimization of Grape Seed Extract Soft Capsule Preparation by Orthogonal Experiment[J].BEIFANG YAOXUE,2014,0(3):47-48. |
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| Authors: | Li Xufa Tang Xiufang Li Jianying |
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| Institution: | Li Xufa Tang Xiufang Li Jianying(Sirio Pharma Co. Ltd of Guangdong, Shantou 515041, China) |
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| Abstract: | The preparation of Grape Seed Extract Soft Capsule was optimized by orthogonal design with evaluation indexes such as sedimentation ratio and redispersibility, by taking soybean oil as the disperse medium, beeswax as the suspending agent, and soybean phospholipid as the moistening agent. The results showed that the optimal proportion of soft capsule contents were made from Grape Seed Extract. soybean oil. beeswax and soybean phospholipid （18.2：72.8：6：3）and the contents of soft capsule were well distributed with good stabilization and fluidity. |
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| Keywords: | Grape Soft capsule Orthogonal design Content |
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